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Randomized clinical trial between Fluoxetine and Dapoxetine treatment among premature ejaculation’s men and its effect on marital satisfaction

Che Man, Mohammad and Mohd Zain, Faridah and Che Alhadi, Shahidah and Yaacob, Najib Majdi and Ismail, Shaiful Bahari (2021) Randomized clinical trial between Fluoxetine and Dapoxetine treatment among premature ejaculation’s men and its effect on marital satisfaction. IIUM Medical Journal Malaysia (IMJM). ISSN 1823-4631 (In Press)

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Abstract

Introduction: Premature ejaculation(PE) decreases sexual pleasure and quality of life, and both Fluoxetine and Dapoxetine were used in PE therapy. Dapoxetine is the first SSRI with short half-life and less side effects, primarily designed for PE therapy. Aims: To evaluate and compare the effects of Fluoxetine and Dapoxetine on PE symptoms and marital satisfaction. Methods: 44 participants aged between 18 and 64 with a PEDT score of ≥9 from Hospital USM's Primary Care Clinic, Kelantan Malaysia were selected and randomized into two groups: Fluoxetine(FG) and Dapoxetine Group(DG), and administered for 8 weeks with either regular Fluoxetine(20mg) or Dapoxetine (30mg) on demand at least once a week. Main Outcome Measures: Premature Ejaculation Diagnostics Tool(PEDT) score were used to assess PE symptoms and Dyadic Satisfaction-Dyadic Adjustment Scale(DS-DAS) used to evaluate marital satisfaction at baseline and at the 8th week. RESULTS: 22 and 21 participants in FG and DG completed the study. For both groups PEDT scores decreased substantially [from 11.41 to 5.45(P<0.001) among FG, from 13.43 to 3.10(P<0.001) among DG]. After adjustment of the baseline PEDT score, PEDT scores in DG(6.03 vs 2.49, P<0.001) were lower at 8th week. Both groups showed significantly improved DS-DAS scores [from 34.50 to 40.68(P<0.001) in FG, from 36.57 to 44.33(P<0.001) in DG]. No marked difference in DS-DAS scored after adjustment of the baseline DS-DAS score(41.13 vs 43.86, P=0.055) at the end of assessment. CONCLUSION: Treatment of PE with either Fluoxetine or Dapoxetine decreases PE symptoms and increases marital satisfaction.

Item Type: Article (Journal)
Additional Information: 6884/85732
Uncontrolled Keywords: Premature ejaculation, Dapoxetine, Fluoxetine
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RZ Other systems of medicine
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Family Medicine (Effective: 1st January 2011)
Kulliyyah of Medicine > Department of Surgery
Kulliyyah of Medicine
Depositing User: SR NUR FARHANA LATFI
Date Deposited: 16 Dec 2020 11:22
Last Modified: 16 Dec 2020 11:26
URI: http://irep.iium.edu.my/id/eprint/85732

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