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Evaluation and comparison of Trachyspermum ammi seed extract for its anti-inflammatory effect

Aslam, Adeel and Nokhala, Ahmed and Peerzada, Sohaib and Ahmed, Shoaib and Khan, Tanveer and Siddiqui, Mohammad Jamshed Ahmad (2020) Evaluation and comparison of Trachyspermum ammi seed extract for its anti-inflammatory effect. Journal of Pharmacy & Bioallied Sciences, 12 (6). pp. 777-780. ISSN 0976-4879 E-ISSN 0975-7406

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Aims and Objectives: The present study was aimed to evaluate the anti-inflammatory effect of different seed extracts of Trachyspermum ammi at different doses. Materials and Methods: Three different seed extracts were prepared through Soxhlet extraction method by using n-hexane, chloroform and methanol solvents. Acute toxicity test performed at dose of 400 mg/kg, 800 mg/kg, 1600 mg/kg and 3200 mg/kg. Two different strengths of seed extracts (minimum therapeutic dose of 500 mg/kg and maximum therapeutic dose of 1000 mg/kg) were given to Wistar rats to measure anti-inflammatory activity through Carrageenan induced paw edema method. Results: The standard drug diclofenac sodium was (percentage of inhibition of paw edema 29.68%) more effective as compared to test drug. When efficacy of all extracts compared with each other, n-hexane extract showed more anti-inflammatory effect (percentage inhibition of paw edema 22.21%) at maximum effective dose 1000 mg/kg. Conclusion: Seed extracts of T. ammi showed anti-inflammatory activity by potentiating the neurotransmission of GABA and also by repression glutamate receptor.

Item Type: Article (Journal)
Additional Information: 6804/85392
Uncontrolled Keywords: Acute toxicity, anti-inflammatory, Trachyspermum ammi
Subjects: Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Kulliyyah of Pharmacy > Department of Pharmacy Practice
Depositing User: Dr M Jamshed Siddiqui
Date Deposited: 01 Dec 2020 10:21
Last Modified: 01 Dec 2020 10:21
URI: http://irep.iium.edu.my/id/eprint/85392

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