Periodic assessment of (ET-1) and Nitric Oxide (NO) in hypertensive disorders of pregnancy (HDP)

Ismawi, Hidayatul Radziah and Abdul Razak, Tariq and Jamani, Nurjasmine Aida and Mohd Zainudin, Maizura (2019) Periodic assessment of (ET-1) and Nitric Oxide (NO) in hypertensive disorders of pregnancy (HDP). In: The 9th Federation of the Asian and Oceanian Physiological Societies Congress, 28th - 31st March 2019, Kobe, Japan. (Unpublished)

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Abstract

INTRODUCTION Hypertensive Disorders of Pregnancy (HDP) is an independent risk factor of cardiovascular (CVS) disease. Endothelin-1 (ET-1), a potent vasoconstrictor, has been identified as a pivotal mediator in both essential hypertension and HDP. Disturbances in Nitric Oxide (NO) bioavailability found in endothelial dysfunction may increase susceptibility to cardiovascular diseases. METHODOLOGY Thirty six pregnant women at 30-36 weeks period of gestation from the following categories (i) pregnancy induced hypertension (PIH) (ii) chronic hypertension during pregnancy (CH) and (iii) normal pregnant women (Control). Blood pressure indices measurements and sample collection was done at antepartum (30-36 weeks), post partum (8 weeks and 12 weeks). Endothelin-1 and serum NO were measured using the Human ET-1 (Endothelin-1) and NO ELISA Kit. RESULTS All blood pressure indices were significantly higher in HDP patients compared to control during antenatal and post partum periods. Serum ET-1 was significantly higher in patients with HDP compared to control during antenatal until 3 months post partum. This was accompanied by significantly lower levels of serum NO in HDP patients. CONCLUSION Persistently high levels of ET-1 and low levels of NO up to 3 months post partum in patients with history of HDP indicate presence of persistent endothelial dysfunction despite BP normalisation in PIH patients. Long term NO/ET-1 imbalance may account for the increased CVS disease risk.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	5472/83592
Uncontrolled Keywords:	Hypertensive disorders of pregnancy (HDP), Endothelin-1 (ET-1), nitric oxide (NO), persistent endothelial dysfunction
Subjects:	R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System R Medicine > RG Gynecology and obstetrics R Medicine > RG Gynecology and obstetrics > RG551 Pregnancy
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Family Medicine (Effective: 1st January 2011)
Depositing User:	Dr Hidayatul Radziah Ismawi
Date Deposited:	13 Oct 2020 09:53
Last Modified:	13 Oct 2020 09:53
URI:	http://irep.iium.edu.my/id/eprint/83592

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