The changes of dermal capillary morphology in different types of diabetic foot ulcer patients.

Mohd Radzuan, Hazulin and Myint, Yi Yi and Tun, Ye and Zulkifly, Ahmad Hafiz (2012) The changes of dermal capillary morphology in different types of diabetic foot ulcer patients. In: IIUM 1st International Postgraduate Research Conference, 20-22 February 2012, Gombak, Kuala Lumpur. (Unpublished)

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Abstract

Introduction Morphological changes affecting skin microvasculature in diabetic foot ulcer (DFU), including dermal capillaries, may indicate microcirculatory dysfunction and subsequently affects the patient’s outcome. Methods We studied 42 subjects, involving 10 controls, 16 with neuropathic DFU and 16 with neuroischaemic DFU. The specimens were taken by using skin punch biopsy and routinely processed for light microscopy. We calculated and measured the luminal area : outer vessel area ratio in percentage (LA) from 3 selected capillaries in each slide of every patient and means of these reading were recorded. Results There were significant decrement in LA among the diseased group as compared to the controls, F (2, 39) = 17.54, p < 0.05. The Tukey post-hoc comparisons indicate that the LA between neuropathic and neuroischemic group was also significant as p < 0.05. Conclusion Decrement of LA among different types of DFU patients shows dermal capillaries adaptation towards diabetic state, thus causing restriction in the patency of skin microvasculature. This finding also supports the presence of intermittent claudication, particularly in neuroischemic DFU patients.

Item Type:	Conference or Workshop Item (Invited Papers)
Additional Information:	6345/83278
Uncontrolled Keywords:	diabetic foot ulcer, skin microcirculation, dermal capillaries luminal area, intermittent claudication
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General) R Medicine > RB Pathology R Medicine > RC Internal medicine > RC627 Specialties of Internal Medicine-Metabolic Diseases R Medicine > RD Surgery R Medicine > RD Surgery > RD701 Orthopedics R Medicine > RD Surgery > RD92 Wounds and injuries
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation
Depositing User:	Dr Hazulin Mohd Radzuan
Date Deposited:	27 Dec 2020 16:19
Last Modified:	27 Dec 2020 16:19
URI:	http://irep.iium.edu.my/id/eprint/83278

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