IIUM Repository

Medicinal properties screening of Mallotus paniculatus extract

Bahaman, NA and Ahmad Raus, Raha and Ahmad Nor, Yusilawati and Mamun, Abdullah Al and Adzahar, Noor Suhana and Basri, Dayang Fredalina (2020) Medicinal properties screening of Mallotus paniculatus extract. IIUM Medical Journal Malaysia, 19 (1). pp. 5-12. E-ISSN 1823-4631

PDF (full text) - Published Version
Download (1MB) | Preview
PDF (scopus) - Supplemental Material
Download (733kB) | Preview


Traditionally, Mallotus paniculatus (Balik Angin) plant is used in the treatment of various diseases in rural areas such as remedy after childbirth, wound healing and fever. In this present study, four medicinal properties of the plant were investigated which included antibacterial, antifungal, anticancer and antioxidant activities. Materials and Methods: Potential medicinal compounds were extracted from the plant leaves by sonication with 3 different solvents namely ethanol, ethyl acetate and hexane respectively. The antibacterial and antifungal properties were determined using disc diffusion agar and broth dilution assay, the antioxidant activity by DPPH scavenging assay and the anticancer effect by MTT assay. Results: From the screening of the medicinal properties, M. paniculatus leave extracts were shown to possess antibacterial, antioxidant and anticancer properties but not antifungal properties. Ethanolic and ethyl acetate extracts of the leave were active against gram positive bacteria (Staphylococcus aureus and Bacillus subtilis) but not gram negative bacteria (Pseudomonas aeruginosa and Escherichia coli). The antioxidant activity of the ethanolic crude extract was high; with IC50 of 30 μg/ml comparable with the positive controls; ascorbic acid and butylated hydroxytoluene (BHT). Both ethanolic and ethyl acetate extracts were cytotoxic against breast cancer (MCF7), colon cancer (HT-29), cervix cancer (Hela) cell lines. Conclusion: M. paniculatus leave extract has many potential medicinal values for further studies.

Item Type: Article (Journal)
Additional Information: 5174/82968
Uncontrolled Keywords: Mallotus paniculatus, antibacterial, anticancer, antioxidant, sonication
Subjects: R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Engineering > Department of Civil Engineering
Kulliyyah of Engineering
Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User: Dr Abdullah Al Mamun
Date Deposited: 15 Sep 2020 10:46
Last Modified: 15 Sep 2020 10:46
URI: http://irep.iium.edu.my/id/eprint/82968

Actions (login required)

View Item View Item


Downloads per month over past year