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Effect of processing methods on xylitol-starch base co-processed adjuvant for orally disintegrating tablet application

Bin, Liew Kai and Mohammed Helaluddin, Abul Bashar and Islam Sarker, Md. Zaidul and Mandal, Uttam Kumar and Gaurav, Anand (2020) Effect of processing methods on xylitol-starch base co-processed adjuvant for orally disintegrating tablet application. Pakistan Journal of Pharmaceutical Sciences, 33 (2). pp. 551-559. ISSN 1011-601X

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Orally disintegrating tablet (ODT) is a friendly dosage form that requires no access to water and serves as a solution to non-compliance. There are many co-processed adjuvants available in the market. However, there is no single product possesses all the ideal characteristics such as good compressibility, fast disintegration and good palatability for ODT application. The aim of this research was to produce a xylitol-starch base co-processed adjuvant which is suitable for ODT application. Two processing methods namely wet granulation and freeze drying were used to compare the characteristics of co-processed adjuvant comprising of xylitol, starch and crospovidone XL-10 mixed at various ratios. The co-processed excipients were compressed into ODT and physically characterized for powder flow, particle size, hardness, thickness, weight, friability, in-vitro disintegration time and in-situ disintegration time, lubricant sensitivity, dilution potential, Fourier transform infrared spectroscopy, scanning electronic microscopy and x-ray diffraction analysis. Formulation F6 was selected as the optimum formulation due to the fastest in-vitro (135.33±11.52 s) and in-situ disintegration time (88.67±13.56s) among all the formulations (p<0.05). Increase in starch component decreases disintegration time of ODT. The powder flow fell under the category of fair flow. Generally, it was observed that freeze drying method produced smaller particle size granules compared to wet granulation method. ODT produced from freeze drying method had shorter disintegration time compared to ODT from wet granulation batch. In conclusion, a novel co-processed excipient comprised of xylitol, starch and crospovidone XL-10, produced using freeze drying method with fast disintegration time, good compressibility and palatability was developed and characterized. The co-processed excipient is suitable for ODT application.

Item Type: Article (Journal)
Additional Information: 4478/82500
Uncontrolled Keywords: Co-processed adjuvant, Crospovidone, Freeze drying, Starch, Xylitol
Subjects: R Medicine > R Medicine (General)
R Medicine > RK Dentistry > RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Professor Md. Zaidul Islam Sarker
Date Deposited: 28 Aug 2020 10:32
Last Modified: 28 Aug 2020 10:32
URI: http://irep.iium.edu.my/id/eprint/82500

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