Phenolic compounds of aqueous and Methanol extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes caps: antioxidant and antiproliferative activities

Ukaegbu, Chinonso Ishmael and Shah, Samiur Rashid and Abd Hamid, Hazrulrizawati and Alara, Oluwaseun Ruth and Sarker, Md. Zaidul Islam (2020) Phenolic compounds of aqueous and Methanol extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes caps: antioxidant and antiproliferative activities. Pharmaceutical Chemistry Journal, 54 (2). pp. 170-183. ISSN 0091-150X E-ISSN 1573-9031

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Abstract

Since the World Health Organization has suggested the exploration of natural products for cancer management owing to the side effects of chemotherapy and irradiation on humans and breast cancer accounts for the highest number of cancer related deaths globally, this study has examined antiproliferative effects of the aqueous and methanol extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes caps against two breast cancer cell lines. The antioxidant and antiproliferative activities of these mushroom extracts were evaluated in vitro using chemical-based (for antioxidant activity) and cell (for antiproliferative activity) approaches. Furthermore, the phytochemical composition of the mushroom extracts were identified using mass spectroscopy (UPLC-QTOF/MS). The obtained results showed aqueous extracts of F. velutipes (Enoki) and white H. tessellatus (Bunapi shimeji) caps to possess higher antiodixant activities against DPPH (IC50 = 0.202 and 0.573 mg/mL, respectively), and H2O2 (IC50 = 0.622 and 0.745 mg/mL, respectively) compared tothe methanol extracts. Aqueous extracts of the mushrooms also showed better ferric reducing antioxidant power (FRAP) values against ferric ions compared to the methanol extracts. Finally, the mushroom extracts showed good antiproliferative activities against human breast cancer cell lines. These findings suggest the presence of phytochemicals with antiproliferative and antioxidant acrtivities in the mushroom extracts studied.

Item Type:	Article (Journal)
Additional Information:	6605/82493
Uncontrolled Keywords:	antioxidant, antiproliferative, F. Velutipes, H. tessellatus, phytochemicals
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Professor Md. Zaidul Islam Sarker
Date Deposited:	28 Aug 2020 10:47
Last Modified:	28 Aug 2020 10:47
URI:	http://irep.iium.edu.my/id/eprint/82493

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