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Trihoney ameliorates hypercholesterolemia-induced epididymal histopathological changes in male rabbits

Hamad Mohamed, Zenab and Ibrahim, Muhammad and Hamad Alfarisi, Hamad Abdulsalam and Abdul Wahab, Azantee Yazmie and Abd. Fuaat, Azliana and Che Mohamad, Che Anuar (2020) Trihoney ameliorates hypercholesterolemia-induced epididymal histopathological changes in male rabbits. Asia-Pacific Journal of Molecular Biology and Biotechnology, 28 (1). pp. 90-100. ISSN 0128-7451

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Abstract

Hypercholesterolemia has been linked to weight change and histopathological alteration of male reproductive organs. The epididymis was suggested to be an early target of lipid-related infertility and can be dramatically affected by excess intake of a high cholesterol diet. On the other hand, the interest has been increased towards the use of honey as a prophylactic and therapeutic agent for various diseases. Therefore, the purpose of this study is to investigate the effects of Trihoney (a mixture of Trigona, Mellifera and Tualang) on epididymal weight change and histopathological alterations in hypercholesterolemic male rabbits and compare its effects with atorvastatin. Forty-eight mature male New Zealand white rabbits were divided into 6 groups. Two groups received standard rabbit pellet with 0 and 0.6 g/kg/day of Trihoney respectively while the other four groups received 1% cholesterol diet with 0, 0.3, 0.6 g/kg/day of Trihoney, and 2 mg/kg/day of atorvastatin. After 12 weeks, the rabbits were sacrificed and the epididymides were harvested for evaluation of weight and histopathological changes. Administration of 1% cholesterol diet either alone or in combination with atorvastatin caused a significant reduction in the epididymal weight and epididymal atrophy. Supplementation of Trihoney particularly at the dose of 0.6 g/kg/day improved epididymal weight, regained the normal architecture of the epididymal histology and increased the number of mature sperm inside the tubules of the epididymis. Based on these results, Trihoney exhibited its potential health benefit as a protective agent against epididymal weight reduction and histopathological alterations in hypercholesterolemic rabbits. © 2020, University of Malaya. All rights reserved.

Item Type: Article (Journal)
Additional Information: 4669/81639
Uncontrolled Keywords: atorvastatin, epididymis, histology, hypercholesterolemia, Trihoney
Subjects: R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences
Kulliyyah of Allied Health Sciences > Department of Nutrition Sciences
Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Obstetric & Gynecology
Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Basic Medical Sciences
Depositing User: Muhammad Ibrahim
Date Deposited: 14 Jul 2020 23:53
Last Modified: 14 Jul 2020 23:53
URI: http://irep.iium.edu.my/id/eprint/81639

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