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Anti-inflammatory effects of trihoney in hypercholesterolemic atherosclerotic rabbits: a comparative study with atorvastatin

Hamad Alfarisi, Hamad Abdulsalam and Ibrahim, Muhammad and Azahari, Nuraniza and Hamad Mohamed, Zenab and Hamdan, Asmah Hanim and Che Mohamad, Che Anuar (2020) Anti-inflammatory effects of trihoney in hypercholesterolemic atherosclerotic rabbits: a comparative study with atorvastatin. Malaysian Journal of Medicine and Health Sciences, 16 (2). pp. 230-236. ISSN 1675-8544 E-ISSN 2636-9346

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Introduction: Hypercholesterolemia has been proven as a main pathogenic trigger for pathogenesis of atherosclero- sis. Atherosclerosis characterised by chronic inflammatory process and increased expression of inflammatory mark- ers. In this study; Trihoney (a combination of three types of natural honey namely: Trigona, mellifera, and Dorsata) was investigated for its anti-inflammatory effect in hypercholesterolemic atherosclerotic rabbits. Methods: Thirty male New Zealand white rabbits (NZW) were grouped into: normal diet (C), normal diet with 0.6g/kg/day of Tri- honey (C+H), 1% cholesterol diet (HCD), 1% cholesterol diet with 0.6g/kg/day of Trihoney (HCD+H), and 1% cholesterol diet with 2mg/kg/day of atorvastatin (HCD+At.). After 12 weeks of starting the experiment, animals were sacrificed and serum analysed for homocysteine and pro-atherogenic inflammatory markers such as: interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumour necrosis factor-α (TNF-α). Fasting serum glucose was analysed to assess gly- caemic status. Results: Trihoney treated group showed significantly lower (p<0.05) serum IL-1β and IL-6 compared to the HCD group. Trihoney supplementation resulted in significant (p<0.001) reduction of serum TNF-α compared to HCD group. Experimental group HCD had serum homocysteine level comparable to that of the control groups with- out any significant difference despite little increase in the mean value. Trihoney treated group had serum homocys- teine comparable to the controls. All experimental groups showed fasting serum glucose comparable to the control. Conclusion: This study showed that Trihoney has an anti-inflammatory function and may be used as an adjuvant to statins for management of atherosclerotic cardiovascular diseases even in diabetic subjects. Keywords: Atherosclerosis, Atorvastatin, Inflammatory markers, Trihoney

Item Type: Article (Journal)
Additional Information: 4998/80335
Uncontrolled Keywords: atherosclerosis, atorvastatin, inflammatory markers, trihoney
Subjects: Q Science > Q Science (General) > Q128 Islam and Science
Q Science > Q Science (General) > Q300 Cybernetics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences
Kulliyyah of Allied Health Sciences > Department of Nutrition Sciences
Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Basic Medical Sciences
Date Deposited: 12 Aug 2020 16:42
Last Modified: 21 Nov 2023 09:29
URI: http://irep.iium.edu.my/id/eprint/80335

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