Ogu Salim, Nurhainis and Md Yusuf, Noor Azian and Ahmad Fuad, Fazia Adyani (2019) Plasmodial enzymes in metabolic pathways as therapeutic targets and contemporary strategies to discover new antimalarial drugs: a review. Asia-Pacific Journal of Molecular Biology and Biotechnology, 27 (4). pp. 38-53. E-ISSN 0128-7451
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Abstract
Malaria continues to pose imminent threat to the world population, as the mortality rate associated with this disease remains high. Current treatment relies on antimalarial drugs such as Artemisinin Combination Therapy (ACT) are still effective throughout the world except in some places, where ACT-resistance has been reported, thus necessitating novel approaches to develop new anti-malarial therapy. In the light of emerging translational research, several plasmodial targets, mostly proteins or enzymes located in the parasite’s unique organelles, have been extensively explored as potential candidates for the development of novel antimalarial drugs. By targeting the metabolic pathways in mitochondrion, apicoplast or cytoplasm of Plasmodium, the possibility to discover new drugs is tremendous, as they have potentials as antimalarial therapeutic targets. This literature review summarizes pertinent information on plasmodial targets, especially enzymes involved in specific metabolic pathways, and the strategies used to discover new antimalarial drugs. © 2019, University of Malaya. All rights reserved.
| Item Type: | Article (Journal) |
|---|---|
| Additional Information: | 7200/79762 |
| Uncontrolled Keywords: | Plasmodium enzymes, metabolic pathways, antimalarial target, drug discovery |
| Subjects: | T Technology > TP Chemical technology > TP248.13 Biotechnology |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Engineering Kulliyyah of Engineering > Department of Biotechnology Engineering |
| Depositing User: | Dr Fazia Adyani Ahmad Fuad |
| Date Deposited: | 23 Mar 2020 23:26 |
| Last Modified: | 23 Mar 2020 23:27 |
| URI: | http://irep.iium.edu.my/id/eprint/79762 |
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