Identification of possible compounds possessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis

Khatib, Alfi and Yuliana, Nancy Dewi and Jinap, Selamat and Sarker, Md. Zaidul Islam and Jaswir, Irwandi and Wilson, Erica G. and Shin-Kyo, Chung and Verpoorte, Robert (2009) Identification of possible compounds possessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis. Journal of Liquid Chromatography & Related Technologies, 32. pp. 2906-2916. ISSN 1520-572X (O), 1082-6076 (P)

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Abstract

A novel approach to identify compounds possessing adenosine A1 receptor binding activity in the leaves of O. stamineus was developed. O. stamineus extract is one of the components of a functional beverage used in Indonesia for the treatment of kidney stones. In this study, adenosine A1 receptor binding, which is related to the diuretic action in the treatment of kidney stones was tested. A combination of thin layer chromatography of different extracts prepared by extraction with diverse solvents (n-hexane, chloroform, n-butanol and water), and multivariate data analysis based on orthogonal partial least squares proved to be a promising approach to determine these active compounds. Several methoxyflavonoids, fatty acids or terpenoids were estimated to be relatedto this activity. The results of this study support the traditional use in Indonesia of O. stamineus as a functional drink to treat kidney stones

Item Type:	Article (Journal)
Additional Information:	5784/7964
Uncontrolled Keywords:	Adenosine, Kidney stone, Multivariate data analysis, Orthogonal partial least square, Orthosiphon staminues , TLC
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User:	Prof. Dr. Irwandi Jaswir
Date Deposited:	29 Nov 2011 13:57
Last Modified:	16 Dec 2013 13:03
URI:	http://irep.iium.edu.my/id/eprint/7964

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