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Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach

Ismail, Hakimah and Ahmad, Mohammad Norazmi and Abdullah, Erna Normaya (2019) Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach. In: 32nd International Conference of Analytical Sciences (SKAM32), 14-16 August 2019, Port Dickson. (Unpublished)

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Abstract

A selective and sensitive chemosensor for recognizing Co2+ in water sample was optimized from a heterocyclic thiosemicarbazone derivative named 2-acetylpyrazine thiosemicarbazone (AT). The optimization of AT as chemosensor was conducted through RSM experiments using UV- Vis spectroscopy. The interaction between AT and Co2+ was found to be optimum in 8:2 v/v DMSO/water at pH 5.3, 100:70 μM AT/Co2+ concentration and 15 minutes reaction time. AT- Co2+ interaction showed colorimetric response from colourless to orange, together with peak- shifting in the absorption spectra from 327 nm to 450 nm. The detection limit of AT towards Co2+ was found to be 3.75 μM while the binding stoichiometry of AT-Co2+ was 2:1. The practicality of AT as chemosensor was tested using three different water samples spiked with Co2+ in the optimized condition. The chemical interaction between AT and Co2+ was further studied through computational studies. DFT calculations for molecular electron potential (MEP), Fukui function and HOMO-LUMO interaction were used to support the experimental results.

Item Type: Conference or Workshop Item (Invited Papers)
Additional Information: 7148/79369
Uncontrolled Keywords: Keywords: chemosensor, cobalt ion, 2-acetylpyrazine thiosemicarbazone, UV-Vis spectroscopy, RSM, DFT calculation
Subjects: Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Science > Department of Chemistry
Kulliyyah of Science
Depositing User: Dr Erna Normaya Abdullah
Date Deposited: 06 Apr 2020 21:53
Last Modified: 06 Apr 2020 21:53
URI: http://irep.iium.edu.my/id/eprint/79369

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