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A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum

Sarker, Md. Zaidul Islam and Awang, Anis Fadhlina Izyani and Ahmed, Qamar Uddin and Md. Jaffri, Juliana (2019) A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum. In: AIMST International Pharmacy Conference (AIPC) 2019: Challenges and Opportunities in Pharmaceutical Sciences, Technology and Practice, 30 November - 1 December 2019, Faculty of Pharmacy, AIMST University, Semeling, Kedah. (Unpublished)

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Abstract

Background: Stereospermum fimbriatum or locally known as “Chicha” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. Objective: This study was designed to evaluate the antimicrobial potential of S. fimbriatum’s stem bark against 11 pathogens and isolate its bioactive compound. Material and methods: Successive soxhlet extraction was conducted using n-hexane, dichloromethane (DCM) and methanol. Disc diffusion, minimum inhibitory and bactericidal concentration (MIC & MBC) assays were done to examine the antimicrobial activity. Bioassay-guided isolation was conducted on S. fimbriatum’s extract. Results: The DCM extract of stem bark (DS) was the most potent extract followed by n-hexane extract of the stem bark (NS). A novel compound was isolated and coded as C1 which demonstrated potent antibacterial effects with the MIC values as low as 3.13 μg/mL to 6.25 μg/mL, against S. epidermidis, MRSA and S. aureus. Conclusion: S. fimbriatum could be a potential source of antimicrobial agents for the treatment of skin infections, specifically, MRSA.

Item Type: Conference or Workshop Item (Slide Presentation)
Additional Information: 6605/76986
Uncontrolled Keywords: Stereospermum fimbriatum; Chicha; antibacterial compound; bioassayguided isolation; angucycline.
Subjects: R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Professor Md. Zaidul Islam Sarker
Date Deposited: 18 Dec 2019 09:41
Last Modified: 18 Dec 2019 09:41
URI: http://irep.iium.edu.my/id/eprint/76986

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