Preliminary study in discovering 2-propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)- from syzygium aqueum leaves as a tyrosinase inhibitor in food product: experimental and theoretical approach

Zarudin, Nurul Husna and Abdullah, Erna Normaya and Yunus, Kamaruzzaman and Ku Bulat, Ku Halim and Ahmad, Mohammad Norazmi (2019) Preliminary study in discovering 2-propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)- from syzygium aqueum leaves as a tyrosinase inhibitor in food product: experimental and theoretical approach. In: International Conference on Clean Water, Air and Soil (CLEANWAS 2019), 26th-28th July 2019, Hanoi, Vietnam. (Unpublished)

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Abstract

In this study, response surface methodology (RSM) in combination with central composite rotatable design (CCRD) were performed to optimize the extraction parameters for total phenolic content (TPC) on Syzygium aqueum (S. aqueum) leaves. The effect of operational conditions on the extraction of S. aqueum leaves using carbon dioxide (CO2) on TPC was investigated. The conditions used in the supercritical extraction with CO2 included temperatures of (40-70 °C), pressures (2200-4500 psi) and extraction time (40-100 min). The highest TPC (3.5893 mg GAE/mg) was obtained at optimum conditions of 55 °C, 3350 psi and 70 min. The major compound in the optimized crude extract was2-propen-1-one,1-(2,4Dihydroxyphenyl)-3-(4-methoxyphenyl)- (82.65 %) which was identified by GC-MS. COSMO-RS was introduced to study the σ-profile between CO2 and 2-propen-1-one,1-(2,4-Dihydroxyphenyl)-3-(4methoxyphenyl)-. Principal component analysis (PCA) was performed to classify major compound which exhibit similar chemical properties with selected control. 2-propen-1-one,1-(2,4-Dihydroxyphenyl)-3-(4methoxyphenyl)- has similar chemical properties with kaempferol as tyrosinase inhibitor. Molecular electrostatic potential (MEP) and molecular docking were plotted to investigate a recognition manner of 2-propen-1-one,1-(2,4-Dihydroxyphenyl)-3-(4-methoxyphenyl)-upon tyrosinase receptor.

Item Type:	Conference or Workshop Item (Invited Papers)
Additional Information:	7149/75325
Uncontrolled Keywords:	2-propen-1-one,1-(2,4-Dihydroxyphenyl)-3-(4methoxyphenyl)-, Response Surface Methodology (RSM), Principal Component Analysis (PCA), COSMO RS, Molecular Docking
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Mohammad Norazmi Ahmad
Date Deposited:	14 Nov 2019 09:31
Last Modified:	15 Nov 2019 13:36
URI:	http://irep.iium.edu.my/id/eprint/75325

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