Preliminary investigations of anti-cancer properties of Myrmecodia Pendens on human oral cancer HSC-3 cell lines

Irfanita, Nining and Eddie, Shah and Aziz, N.A. and Ichwan, Solachuddin J. A. and Lestari, Widya (2019) Preliminary investigations of anti-cancer properties of Myrmecodia Pendens on human oral cancer HSC-3 cell lines. In: Conference on BioMedical and Advanced Materials (Bio-CAM 2017), 28th-29th November 2017, Pulau Langkawi, Kedah.

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Abstract

Myrmecodia pendens (M. pendens) or also known as Sarang semut is an epiphytic plant which might have potential as a new source of alternative therapeutic agent. Recently, it is reported that M. pendens can inhibit the proliferation of HeLa and MCM- B2 cell lines. We report here for the first time the anti-cancer potential of M. pendens on oral cancer cells derived from human oral cavity, HSC-3 cell lines. MTT assay results showed that M. pendens crude extract markedly induced cytotoxicity on HSC-3 cell lines after 24 h (IC50 = 5 mg/mL) and 48 h (IC50 = 3 mg/ml). The apoptotic activity induced by M. pendens was detected in HSC-3 cell lines by flow cytometry within 24 h. These results suggest that M. pendens may be a potential candidate for oral cancer treatment

Item Type:	Conference or Workshop Item (Plenary Papers)
Additional Information:	5731/75065
Uncontrolled Keywords:	Sarang semut; Myrmecodia pendens; cytotoxicity; apoptosis; HSC-3 cell lines
Subjects:	R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User:	Dr Widya Lestari
Date Deposited:	08 Nov 2019 10:14
Last Modified:	08 Nov 2019 10:33
URI:	http://irep.iium.edu.my/id/eprint/75065

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