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Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme

Rullah, Kamal and Khye, Saw Phin and Ang, Serene and Mohd Aluwi, Mohd Fadhlizil Fasihi and Lam, Kok Wai (2018) Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme. Jurnal Sains Kesihatan Malaysia (JSKM), 16 (1). pp. 135-143. ISSN 2289-4535

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Abstract

Inhibition of xanthine oxidase (XO) activity is an effective therapeutic approach for the treatment of diseases such as gout and hyperuricemia. Additionally, the use of XO inhibitors can further be extended to injury treatments such as ischemic reperfusion in various organs such as heart, liver and kidney. In this study, 7 aurone compounds were synthesized and tested on XO and compared with the positive control allopurinol. Compound 5e was identified as the most potent compound and was able to inhibit half of XO activity at 33.23 μM followed by compounds 5f and 5d at 210.22 μM and 302.0 μM, respectively. Finally, molecular docking study was conducted to understand the important binding interactions of the selected aurone with the active site of XO.

Item Type: Article (Journal)
Additional Information: 9020/74216
Uncontrolled Keywords: Auron, xantin oksidase, dok, sintesis, biologi
Subjects: R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Kulliyyah of Pharmacy
Depositing User: Dr Kamal Rullah
Date Deposited: 19 Sep 2019 15:12
Last Modified: 19 Sep 2019 15:12
URI: http://irep.iium.edu.my/id/eprint/74216

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