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Ameliorative effects of Aquilaria malaccensis leaves aqueous extract on reproductive toxicity induced by cyclophosphamide in male rats

Abdul Razak, Redzuan Nul Hakim and Ismail, Faridah and Md Isa, Muhammad Lokman and Abdul Wahab, Azantee Yazmie and Muhammad, Hussin and Ramli, Roszaman and Raja Ismail, Raja Arif Shah (2019) Ameliorative effects of Aquilaria malaccensis leaves aqueous extract on reproductive toxicity induced by cyclophosphamide in male rats. Malaysian Journal of Medical Sciences, 26 (1). pp. 44-57. ISSN 1394-195X E-ISSN 2180-4303

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Abstract

Background: Cyclophosphamide (CP) is a widely used anti-neoplastic and immunosuppressive agent that is associated with adverse side effects including reproductive toxicity. Aquilaria malaccensis (AM) is a traditional medicinal plant which was reported to exhibit high anti-oxidant and free radical scavenging properties. The present study was aimed to evaluate the protective effects of AM leaves extract on sperm quality following toxic exposure to CP. Methods: Forty-eight male Sprague Dawley rats were allocated into eight groups of six rats (n = 6): control, CP only (200 mg kg−1 ), AM only (100 mg kg−1 , 300 mg kg−1 and 500 mg kg−1 ) and CP + AM (100 mg kg−1 , 300 mg kg−1 and 500 mg kg−1 ). Animals were sacrificed after 63 days of treatment and the sperm from the caudal epididymis was taken for sperm analysis. Results: The body and the reproductive organs weight, sperm count and motility did not differ between CP and other groups (P > 0.05). A significant increase (P < 0.05) in percentage of the dead and abnormal sperm were seen in the CP alone treated group compared to the control group. Co-administration of AM to the CP exposed rats significantly reduced the (P < 0.05) percentage of abnormal sperm as compared to the CP only group. Conclusion: Overall, the present results represent the potential of AM to protect against CP induced reproductive toxicity.

Item Type: Article (Journal)
Additional Information: 5041/72609
Uncontrolled Keywords: antioxidants, Aquilaria malaccensis, cyclophosphamide, oxidative stress, reproductive toxicity
Subjects: R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Basic Medical
Kulliyyah of Medicine > Department of Obstetric & Gynecology
Depositing User: Dr Muhammad lokman M Isad
Date Deposited: 13 Jun 2019 15:07
Last Modified: 13 Jun 2019 15:07
URI: http://irep.iium.edu.my/id/eprint/72609

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