Potential oral wound healing of topical application of dental gel prepared from Baccaurea angulata fruit in diabetic rats

Abdul Rahman, Mohammad Nasrin and Sukmasari, Susi and Doolaanea, Abd Almonem and Abdul Qader, Omar Abdul Jabbar (2018) Potential oral wound healing of topical application of dental gel prepared from Baccaurea angulata fruit in diabetic rats. Journal of Pharmaceutical Sciences and Research, 10 (1). pp. 167-174. ISSN 0975-1459

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Abstract

Objective: This study investigates the effect of Baccaurea angulata fruit extract towards wound healing activity at tooth extractions sites. Significance: High antioxidant content in underutilised Baccaurea angulata were expected to open up new possibilities for tooth extraction procedure among diabetic patients. Methods: Sprague dawley rats were divided into 6 groups, and l their left mandibular first molar tooth were extracted. The alveolar socket were treated accordingly where group 1, 2, 3, 4, and 5 were diabetic rats (induced using Streptozotocin) applied with plain gel, alveolex, 3%, 5%, and 10% Baccaurea angulata extract respectively. Group 6 were non diabetic rats applied with plain gel. On day 4, 7 and 18, rats were euthanized, and the tissue samples were processed for histomorphological analysis. Results: It was found that Baccaurea angulata does significantly promotes tooth extraction wound healing in diabetic rats comparable to diabetic group treated with alveolex and non-diabetic rats at early phase of the wound. However the positive effect were not obvious at day 7, while at day 18, groups treated with Baccaurea angulata treated group had higher mean scores in most categories although may not statistically significant different. BADG concentration of 4% was found to give the best effects on wound healing. Conclusion: To a certain extent, Baccaurea angulata extract does promotes tooth extraction wound healing in diabetic rats.

Item Type:	Article (Journal)
Additional Information:	8239/71141
Uncontrolled Keywords:	Baccaurea angulat, tooth extraction, wound healing, diabetes, extracts, dental gel
Subjects:	R Medicine > RK Dentistry R Medicine > RK Dentistry > RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Oral Maxillofacial Surgery and Oral Diagnosis Kulliyyah of Dentistry > Department of Paediatric Dentistry and Dental Public Health Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr. Susi Sukmasari
Date Deposited:	14 Mar 2019 11:40
Last Modified:	12 Jul 2019 15:32
URI:	http://irep.iium.edu.my/id/eprint/71141

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