Synthesis and characterisation of rice husk ash silica drug carrier for α-mangostin

Iqbal, Anwar and Shuib, Nur Azfa and Darnis, Deny Susanti and Miskam, Mazidatulakmam Akmam and Abdul Rahman, Nur Ruzaina and Adam, Farook (2018) Synthesis and characterisation of rice husk ash silica drug carrier for α-mangostin. Journal of Physical Science, 29 (3). pp. 95-107. ISSN 1675-3402 E-ISSN 2180-4230

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Abstract

The potential of rice husk ash (RHA) silica prepared via sol-gel method (RHA-Si) as a drug carrier was investigated. The nitrogen adsorption-desorption isotherm of RHA-Si indicates the presence of mesopores and some small percentage of micropores. The Brunauer, Emmett and Teller (BET) surface area of RHA-Si was 589 m2 g–1 and the Barrett-Joyner-Halenda (BJH) pore size was 5.1 nm. The adsorption of α-mangostin was confirmed by Fourier transform infrared (FTIR) spectroscopy and thermogravimetric analysis (TGA). The sample containing α-mangostin was labeled as RHA-Si-α. The BET surface area of RHA-Si-α was 110 m2 g–1 with the BJH pore size of 24.4 nm. The X-ray powder diffraction (XRD) showed that the RHA-Si and RHA-Si-α were amorphous. The disappearance of crystallinity of α-mangostin indicates that the solubility and dissolution of α-mangostin have been improved. The drug release profile indicated a burst release corresponding to 47% of the total drug loading in the first 15 min. The burst release was caused by physically adsorbed drug molecules. The findings suggest that RHA silica has potential application as nano drug carrier.

Item Type:	Article (Journal)
Additional Information:	5641/70684
Uncontrolled Keywords:	Rice husk, silica, sol-gel, drug carrier, α-mangostin
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology T Technology > TP Chemical technology T Technology > TP Chemical technology > TP155 Chemical engineering
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Deny Susanti Darnis
Date Deposited:	13 Feb 2019 13:48
Last Modified:	15 Jul 2019 09:10
URI:	http://irep.iium.edu.my/id/eprint/70684

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