IIUM Repository

A clinical update on antibiotic resistance gram-negative bacteria in Malaysia-a review

Fazlul, M. K. K. and Rashid, Shah Samiur and Nazmul, M. H.M. and Sarker, Md. Zaidul Islam and Baharudin, Roesnita and Ramli, Aizi Nor Mazila (2018) A clinical update on antibiotic resistance gram-negative bacteria in Malaysia-a review. Journal of International Pharmaceutical Research, 45. pp. 270-283. ISSN 1674-0440

[img] PDF - Published Version
Restricted to Repository staff only

Download (924kB) | Request a copy
[img] PDF (Scopus) - Supplemental Material
Restricted to Repository staff only

Download (157kB) | Request a copy


Antibiotics are the wonder discoveries to combat microbes. For decades, multiple varieties of antibiotics have been used for therapeutic purposes in hospital settings and communities throughout the world. Unfortunately, bacteria have become resistant to commonly prescribed antibiotics. This review aims to explore the development, challenges, and the current state of antibiotic resistance available literature in Malaysia. Recently published data from Pubmed, Scopus, Google scholar’s and other internet source publication on the antibiotic resistance of gram-negative bacteria were further reviewed and analysed in this study. This review reiterates the antibiotic resistance among the gram-negative bacteria is increasing and they are becoming resistant to nearly all groups of antibiotics. The antibiotic treatments are minimal and hard to treat in multi-drug resistance bacterial infection, resulting in morbidity and mortality. The prevalence rate of antibiotic resistance from the literature suggests that educating patients and the public is essential to prevent and control the spread of antibiotic resistance. In particular, there is an urgent need for a surveillance system of regular monitoring on the microbiomes, the discovery of novel antibiotics and therapeutic application of antibiotics are mandatory.

Item Type: Article (Journal)
Additional Information: 6605/70014
Uncontrolled Keywords: Antimicrobial resistance, Acinetobacter, Pseudomonas
Subjects: R Medicine > RC Internal medicine > RC111 Infectious and Parasitic Diseases
R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
T Technology > TD Environmental technology. Sanitary engineering > TD169 Environmental protection
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Professor Md. Zaidul Islam Sarker
Date Deposited: 23 Jan 2019 14:57
Last Modified: 23 Jan 2019 14:57
URI: http://irep.iium.edu.my/id/eprint/70014

Actions (login required)

View Item View Item


Downloads per month over past year