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Red cell antibody screening: a single centre experience

Muhammad, Siti Aesah @ Naznin and Zainal Azhar, Syifa and Meor Jamaludin, Wan Husna Barakah and A. Talib, Norlelawati and Hamdan, Asmah Hanim and Abd. Fuaat, Azliana and Abdullah, Nor Zamzila and Shaik Daud, Shaik Farizan (2018) Red cell antibody screening: a single centre experience. International Medical Journal Malaysia, 17 (Supplementary Issue No 1). p. 33. E-ISSN 1823-4631

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Abstract

The Transfusion Unit of International Islamic University Medical Centre (IIUM MC) performs screening for red cell antibodies for all patients who are to be or might be transfused with red cell components. There are two types of red cell antibodies, the alloantibodies and autoantibodies. While the red cell autoantibodies are produced against self-antigen, the alloantibodies are the results of sensitization through transfusion or pregnancies. These antibodies are implicated in haemolytic transfusion reactions. This retrospective study examines the prevalence of red cell antibodies among patients of IIUM MC. Materials and Methods: All group cross matching and group screen and hold testing performed in IIUM MC from January 2017 to June 2018 were reviewed. Results: In total, samples of 3,712 patients were subjected to antibody screening using gel card. Twelve patients (0.32%) had positive antibody screening tests. The age ranged from 17 to 77 years. Nine (75%) patients were females. Four patients had positivity with Screening Cell I, one patient with Screening Cell II and III respectively. In the remaining patients (6/12) the antibody screening was positive for both Screening Cell I and II. In nine patients (0.24%) alloantibodies were identified, with six exhibiting multiple antibodies. The alloantibodies identified include anti-Le(a), anti-Le(b), anti-Kp(a), anti-C, anti-c, anti-E and anti-e. In three patients autoantibodies with no specificities were detected. Conclusion: Although the prevalence of red cell antibodies, specifically the alloantibodies is lower compared to other studies, the finding further reiterates the need to screen for unexpected red cell antibodies prior to red cell transfusion.

Item Type: Article (other)
Additional Information: 2863/69378 Medical Research Symposium 2018 / 29th August 2018 / Kulliyyah of Medicine, IIUM, 25200, Kuantan
Uncontrolled Keywords: red cell antibody screening, IIUM Medical Centre
Subjects: R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User: Prof. Dr. Siti Aesah @ Naznin Muhammad
Date Deposited: 18 Jan 2019 15:57
Last Modified: 18 Jan 2019 15:57
URI: http://irep.iium.edu.my/id/eprint/69378

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