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In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities

Azad, Abul Kalam and Laboni, Farhina Rahman and Rashid, Harun and Ferdosh, Sahena and Rashid, Shah Samiur and Kamal, Nurkhalida and Labu, Zubair Khalid and Islam, M. S. and Sarker, Md. Zaidul Islam (2018) In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities. Natural Product Research. ISSN 14786419 (In Press)

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Abstract

The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to streptokinase (64.35%). In DPPH study, petroleum ether soluble fraction (PSF) has exhibited IC50 of 18.83lg/mL while the standard ascorbic acid was 2.48mg/ mL. AQSF profoundly inhibited the lysis of erythrocytes (66.20%) which was insignificantly different (p>0.05) to acetylsalicylic acid (71.98%), the reference. However, AQSF showed a significantly stronger level of protection against heat-induced hemolysis (64.80%) as compared with the acetylsalicylic acid (78.90%). CEE, OF and AQSF have displayed reasonable growth of inhibition of tested bacteria compared to negative control and standard drug (77.50mg of GAE/g).

Item Type: Article (Journal)
Additional Information: 7165/68498
Uncontrolled Keywords: Cuscuta reflexa; Thrombolytic; Antioxidant; Membrane stabilizing; Antimicrobial activity
Subjects: R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Professor Dr. Md. Zaidul Islam Sarker
Date Deposited: 19 Dec 2018 10:35
Last Modified: 07 Jan 2019 15:13
URI: http://irep.iium.edu.my/id/eprint/68498

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