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Expression of gamma glutamyl hydrolase and carbonic anhydrase 9 in oral squamous cell carcinoma and their association with extracapsular spread

Burhanudin, Nor Aszlitah and Kallarakkal, Thomas George (2017) Expression of gamma glutamyl hydrolase and carbonic anhydrase 9 in oral squamous cell carcinoma and their association with extracapsular spread. International Medical Journal of Malaysia, 16 (Supplementary Issus no 2). p. 1. E-ISSN 1823-4631

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Abstract

Introduction: Extracapsular spread (ECS) is one of the most important prognostic factors in oral squamous cell carcinoma (OSCC). Gamma Glutamyl Hydrolase (GGH) is a lysosomal enzyme which is involved in folate homeostasis. It is overexpressed in several human malignancies but its role in OSCC has never been reported. Carbonic Anhydrase 9 (CA9) is a transmembrane glycoprotein and is related to hypoxia. High expression of CA9 has been associated with poor prognosis in several tumours including OSCC. This study was aimed to investigate the expression of GGH and CA9 in OSCC and their potential use as biomarkers to predict ECS. Materials and Methods: Immunohistochemical staining with GGH and CA9 markers were performed in 35 cases of OSCC (19 with ECS and 16 without ECS) and 5 cases of normal mucosa. A semi-quantative index was used for immunoscoring. Association between the expression of these markers and ECS status were analyzed using chi-square test. Results: Immunohistochemical results indicated that GGH and CA9 were upregulated in OSCC. High GGH and CA9 expression were significantly associated with ECS (p<0.05). Combination of GGH and CA9 showed greater prognostic accuracy as compared to the individual markers. Conclusion(s): Both separately and in combination GGH and CA9 offer potential as prognostic biomarkers in OSCC and was thus reliable in segregating the OSCC cases based on ECS status.

Item Type: Article (Meeting Abstract)
Additional Information: 6664/66746
Uncontrolled Keywords: carbonic anhydrase 9, extracapsular spread, gamma glutamyl hydrolase, OSCC
Subjects: R Medicine > RK Dentistry > RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Dentistry > Oral Maxxilofacial Surgery & Oral Diagnosis
Kulliyyah of Dentistry
Depositing User: Dr Nor Aszlitah Burhanudin
Date Deposited: 22 Oct 2018 09:15
Last Modified: 22 Oct 2018 09:15
URI: http://irep.iium.edu.my/id/eprint/66746

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