Development of porous PCL-based microcarrier

Mohd. Salleh, Hamzah and Hashim, Yumi Zuhanis Has-Yun and Samsudin, Nurhusna and Abdul Halim, Muhammad A. N. (2018) Development of porous PCL-based microcarrier. In: International Conference on Halal Innovation in Products and Services 2018 (i-CHIPS 2018), 13th-14th July 2018, Haat Yai, Songkhla, Thailand.

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Abstract

Polycaprolactone (PCL) has been used for cell cultivation due to its biocompatibility. However, fabrication of porous PCL microcarrier was an obstacle and study of its biodegradability is also limited. In the present study, PCL-based porous microcarrier was fabricated with different parameters by using emulsion evaporation method. From the study, at 20% camphene concentration, optimum pore size was generated which was at 11.738 μm. During the fabrication of the microcarrier, most of the parameters showed effect on the size of the microcarrier. Under the biodegradability test, it showed that the porous structure of the microcarrier enhance the degradation rate of the microcarrier. Throughout the study, all the parameters tested for the fabrication of microcarrier showed effect on it and the porous structure improve the degradation rate of PCL microcarrier.

Item Type:	Conference or Workshop Item (Plenary Papers)
Additional Information:	1813/65249
Uncontrolled Keywords:	Halal, Microcarrier, Cell culture, Porous, Polycaprolactone
Subjects:	T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	International Institute for Halal Research and Training (INHART) Kulliyyah of Engineering Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User:	Dr Hamzah Mohd. Salleh
Date Deposited:	30 Jul 2018 10:25
Last Modified:	04 Jan 2019 15:46
URI:	http://irep.iium.edu.my/id/eprint/65249

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