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Incorporation of the microencapsulated antimicrobial agent phytoncide into denture base resin

Steve, An and Judge, Roy B and Wong, Rebecca H and Arzmi, Mohd Hafiz and Palamara, J E and Dashper, Stuart (2018) Incorporation of the microencapsulated antimicrobial agent phytoncide into denture base resin. Australian Dental Journal, 63 (3). pp. 302-311. ISSN 1834-7819

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Background This study aimed to fabricate a denture base resin (DBR) containing phytoncide microcapsules (PTMCs) and determine the mechanical properties of the resin and antifungal activity. Methods Fifty‐four heat cured rectangular DBR specimens (64 x 10 x 3.3 ± 0.2 mm) containing nine concentrations of PTMC between 0 ‐ 5% (wt/wt) were fabricated and subjected to a three‐point bending test. A phytoncide release bioassay was developed using DBR containing 0% and 2.5% PTMCs (wt/wt) in a 24 well‐plate assay with incubation of Porphyromonas gingivalis at 37°C for 74 h. The antifungal activity of PTMCs against Candida albicans, in a pH 5.5 acidic environment was determined in a plate assay. Results Flexural strength decreased with increasing PTMC concentration from 97.58 ± 4.79 MPa for the DBR alone to 53.66 ± 2.46 MPa for DBR containing 5.0% PTMC. No release of phytoncide from the PTMCs in the DBR was detected at pH 7.4. The PTMCs had a minimal inhibitory concentration of 2.6% (wt/vol) against C. albicans at pH 5.5. Conclusions PTMCs can be added to DBR 2.5% (wt/wt) without adversely affecting flexural strength. PTMCs released the antimicrobial agent at pH 5.5 at concentrations sufficient to inhibit the growth of the C. albicans.

Item Type: Article (Journal)
Additional Information: 7885/64442
Uncontrolled Keywords: antimicrobial activity, denture base resin, mechanical property, microencapsulation, phytoncide
Subjects: Q Science > QR Microbiology
R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Dentistry
Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User: Dr Mohd Hafiz Arzmi
Date Deposited: 10 Jul 2018 16:18
Last Modified: 31 Jan 2019 14:38
URI: http://irep.iium.edu.my/id/eprint/64442

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