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Tualang honey effects on high cholesterol diet induced nonalcoholic steatohepatitis in an animal model

Hamad Mohamed, Zenab B. and Hamad Alfarisi, Hamad Abdulsalam and Abdullah, Nor Zamzila and Harun, Norra and Muhammad, Naznin and Abdul Rahim, Roslina (2018) Tualang honey effects on high cholesterol diet induced nonalcoholic steatohepatitis in an animal model. World Journal Of Pharmacy And Pharmaceutical Sciences, 7 (2). pp. 1383-1396. ISSN 2278-4357

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Abstract

Aim: This study aimed to examine the effects of tualang honey against the high cholesterol diet induced biochemical and histological changes in the liver and pancreas. Methods: Female Sprague-Dawley rats were used, where the control group (n = 5) was fed with commercial rat pellet; the high cholesterol diet (HCD) group (n= 5) was given 12% cholesterol diet; while the HCD with tualang honey (HCD+TH) group (n =5) was fed with 12% cholesterol diet with daily 1.4 g/kg/day of tualang honey. Blood biochemical analysis were analysed at 1 week and 6 weeks. The liver and pancreas tissues were harvested at the end of 6 weeks for histological examination. Results: The cholesterol diet induction resulted in dyslipidaemia and abnormal liver function. The HCD+TH group have shown an increase in total cholesterol, LDL-c, ALP levels and decreased TG, HDL-c and AST levels significantly at the end of 6 weeks compared to HCD group. The mean plasma glucose level was elevated at 1 week in the HCD group. Plasma insulin levels were higher in HCD+TH group at both 1 and 6 weeks. The HOMA-IR was also higher at 1 week in the HCD+TH group. The liver histology of both HCD and HCD+TH groups showed steatohepatitis with minimal hepatocyte degeneration while the pancreatic sections revealed no abnormalities. Conclusion: The cholesterol diet of 6 weeks duration in this study did induce some features of NASH with dyslipidaemia with abnormal liver profile. Low dose of Tualang honey supplementation exhibited no effect on dyslipidaemia and histopathological changes.

Item Type: Article (Journal)
Additional Information: 3746/61863
Uncontrolled Keywords: High Cholesterol Diet, Tualang Honey, Non Alcoholic Steatohepatitis
Subjects: Q Science > QP Physiology
R Medicine > R Medicine (General)
R Medicine > RB Pathology
R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology
R Medicine > RC Internal medicine > RC803 Specialties of Internal Medicine-Diseases of The Digestive System. Gastroenterology
R Medicine > RD Surgery
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Basic Medical
Depositing User: Dr ROSLINA ABDUL RAHIM
Date Deposited: 09 Feb 2018 16:26
Last Modified: 10 Jun 2018 12:33
URI: http://irep.iium.edu.my/id/eprint/61863

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