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Rheological characterization of different gelling polymers for dental gel formulation

Abdul Rahman, Mohammad Nasrin and Abdul Qader, Omar Abdul Jabbar and Sukmasari, Susi and Ismail, Ahmad Faisal and Doolaanea, Abd Almonem (2017) Rheological characterization of different gelling polymers for dental gel formulation. Journal of Pharmaceutical Sciences and Research, 9 (12). pp. 2633-2640. ISSN 0975-1459

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Abstract

Objective: This study is aimed to select the best gelling agents as candidates to be developed into dental gels, based on their rheological profiles. Significance: This study opens up more options for dental gel formulator to choose regarding the range of good gelling polymers, as the vehicle for their pharmaceutical active ingredients. Methods: 11 types of gelling agents, which consist of 1%, 3%, and 5% w/w concentration for each gel, were prepared. The rheological profiles were measured using rheometers, and the data was analyzed to calculate their apparent viscosities, rheological modelling, and the linear viscoelastic range profiles. Results: It was found that 3%, 5% carbopol 940, 5% guar gum, 5% ι-carrageenan 3% kelcogel F, 1%, 3%, and 5% w/w konjac gum are the best candidates to be developed into dental gels based on their rheological properties. They exhibit good viscoelastic properties, acceptable viscosity profiles at three different shear rates of 10 s-1, 50 s-1, and 100 s-1 Pas, having high consistency factor (K), best flow behaviour (n) value, high G’ value, G’=G” value, and the crossing point of G’ and G” happens at further shear stress range compared to other gels. Conclusion: All the rheological profiles for each of the gels at 3 different concentrations were successfully characterized, analyzed and documented.

Item Type: Article (Journal)
Additional Information: 8239/61333
Uncontrolled Keywords: gels, rheology, viscosity, shear stress, linear viscoelasticity range, gelling polymers
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Dentistry > Oral Maxxilofacial Surgery & Oral Diagnosis
Kulliyyah of Dentistry > Paediatric Dentistry, Orthodontics & Dental Public Health
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr Ahmad Faisal Ismail
Date Deposited: 12 Jan 2018 15:25
Last Modified: 25 Mar 2018 17:15
URI: http://irep.iium.edu.my/id/eprint/61333

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