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Understanding evolutionary processes in bird species using genome-wide sequence analysis

Eltayeb, Muhammad Alfatih and Tumian, Afidalina (2017) Understanding evolutionary processes in bird species using genome-wide sequence analysis. In: The 4th Asian Regional Conference on Systems Biology 2017 (ARCSB2017), 20th-22nd November 2017, Marriott Hotel, Putrajaya. (Unpublished)

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Abstract

Meiotic recombination is the driving force behind genetic diversity. It happens non-randomly across the genome, with high concentrations in regions called recombination hot spots. Across mammalian species, PRDM9 has shown to be an important player in localizing almost all meiotic recombination hot spots. However in some species such as birds and dogs, it is discovered that the localization of hot spots is unlikely to be regulated by PRDM9 due to disruption to its coding sequence. The rapid evolution of PRDM9 maybe a response to escape the self-disruptive drive called biased gene conversion (BGC). In this paper, we attempt to uncover if we can see any signatures of BGC in bird species by using alignment data consisting of the chicken, domestic turkey, zebra finch and the green anole. By studying relative motif losses and gains across the genomes, we aim to understand the biases and target sites/motifs and consequently to infer recombination lifetimes.

Item Type: Conference or Workshop Item (Speech/Talk)
Additional Information: 4915/60944
Uncontrolled Keywords: bird species, genome-wide sequence
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Information and Communication Technology > Department of Computer Science
Kulliyyah of Information and Communication Technology > Department of Computer Science
Depositing User: Dr Afidalina Tumian
Date Deposited: 23 Jan 2018 15:15
Last Modified: 23 Jan 2018 15:15
URI: http://irep.iium.edu.my/id/eprint/60944

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