IIUM Repository

Potential oral wound healing of topical application of dental gel prepared from baccaurea angulata fruit in diabetic rats

Abdul Qader, Omar Abdul Jabbar and Sukmasari, Susi and Doolaanea, Abd Almonem and Abdul Rahman, Mohammad Nasrin and Ismail, Ahmad Faisal and Ibrahim, Muhammad (2017) Potential oral wound healing of topical application of dental gel prepared from baccaurea angulata fruit in diabetic rats. Research Report. UNSPECIFIED. (Unpublished)

[img]
Preview
PDF (Full Version of Research Report RIGS15-047-0047) - Updated Version
Download (1MB) | Preview

Abstract

Objective: This study investigates the effect of Baccaurea angulata fruit extract towards wound healing activity at tooth extractions sites. Significance: High antioxidant content in underutilised Baccaurea angulata were expected to open up new possibilities for tooth extraction procedure among diabetic patients. Methods: Sprague dawley rats were divided into 6 groups, and l their left mandibular first molar tooth were extracted. The alveolar socket were treated accordingly where group 1, 2, 3, 4, and 5 were diabetic rats (induced using Streptozotocin) applied with plain gel, alveolex, 3%, 5%, and 10% Baccaurea angulata extract respectively. Group 6 were non diabetic rats applied with plain gel. On day 4, 7 and 18, rats were euthanized, and the tissue samples were processed for histomorphological analysis. Results: It was found that Baccaurea angulata does significantly promotes tooth extraction wound healing in diabetic rats comparable to diabetic group treated with alveolex and non-diabetic rats at early phase of the wound. However the positive effect were not obvious at day 7, while at day 18, groups treated with Baccaurea angulata treated group had higher mean scores in most categories although may not statistically significant different. BADG concentration of 4% was found to give the best effects on wound healing. Conclusion: To a certain extent, Baccaurea angulata extract does promotes tooth extraction wound healing in diabetic rats.

Item Type: Monograph (Research Report)
Uncontrolled Keywords: Keywords: Baccaurea angulata, tooth extraction, wound healing, diabetes, extracts, dental gel
Subjects: R Medicine > RK Dentistry
R Medicine > RK Dentistry > RK529 Oral Surgery-General Works
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Dentistry > Fundamental Dental and Medical Sciences
Depositing User: Mr Mohammad Nasrin Abdul Rahman
Date Deposited: 18 Dec 2017 17:43
Last Modified: 18 Dec 2017 17:43
URI: http://irep.iium.edu.my/id/eprint/60563

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year