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Enrichment, in vitro, and quantification study of antidiabetic compounds from neglected weed Mimosa pudica using supercritical CO2 and CO2-Soxhlet

Tunna, Tasnuva Sarwar and Sarker, Md. Zaidul Islam and Ghafoor, Kashif and Ferdosh, Sahena and Md Jaffri, Juliana and AL-Juhaımı, Fahad Y.I. and Ali, Md Eaqub and Akanda, Md Jahurul Haque and Awal, Md Shihabul and Ahmed, Qamar Uddin and Selamat, Jinap (2018) Enrichment, in vitro, and quantification study of antidiabetic compounds from neglected weed Mimosa pudica using supercritical CO2 and CO2-Soxhlet. Separation Science and Technology, 53 (2). pp. 243-260. ISSN 0149-6395 E-ISSN 1520-5754

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Abstract

Supercritical fluid extraction (SFE) using carbon dioxide (CO2) and liquid CO2 using Soxhlet (CO2-Soxhlet) extraction were employed to extract three (3) antidiabetic compounds viz. stigmasterol, quercetin, and avicularin from Mimosa pudica. Various extraction parameters were studied. Extracts were analyzed pharmacologically, qualitatively and quantitatively to ascertain enrichment levels. All three antidiabetic compounds were effectively enriched under optimized conditions of temperature 60°C, pressure 40 MPa, co-solvent ratio 30%, and CO2 flow rate of 5 ml min−1. SFE was found to be the better method for enrichment of the antidiabetic compounds than the CO2-Soxhlet method. Extraction conditions were seen to affect the enrichment of desired compounds.

Item Type: Article (Journal)
Additional Information: 6605/60532
Uncontrolled Keywords: Mimosa pudica; supercritical fluid extraction (SFE); CO2-Soxhlet; antidiabetic compounds; α-glucosidase assay
Subjects: R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Science
Depositing User: Professor Dr. Md. Zaidul Islam Sarker
Date Deposited: 27 Dec 2017 18:44
Last Modified: 18 Oct 2018 09:37
URI: http://irep.iium.edu.my/id/eprint/60532

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