Effect of medium-high energy emulsification condition on physicochemical properties of β-sitosterol multiple emulsion

Momeny, Elham and Mirhossein, Hamed and Sarker, Md. Zaidul Islam (2017) Effect of medium-high energy emulsification condition on physicochemical properties of β-sitosterol multiple emulsion. Food Bioprocess Technology, 10 (9). pp. 1642-1654. ISSN 1935-5130 E-ISSN 1935-5149

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Abstract

Phytosterols are used to lower the blood cholesterol. β-Sitosterol isone ofthe mostimportant phytosterolswith verypoorwater solubility and bioaccessibility. The maingoal of the current research was to investigate the effects of different emulsification variables (i.e. shear, time, pressure and cycle) on the physicochemical properties, release behaviour and encapsulation efficiency of β-sitosterol in water-in-oil-in water (W/O/W) emulsion. Initially, 19 β-sitosterol emulsions were prepared under different experimental conditions (shear 3000and6000rpm;time2.5 and 5min;pressure100,200and 300 bar; cycle 1–3). In this study, the β-sitosterol emulsion prepared at 6000 rpm, 5 min, 300 bar and 3 cycles had the smallest average droplet size (139 nm) among all prepared samples. The interaction between shear and time showed the most significant (P < 0.05) effect on the polydispersity index (PDI) and turbidity of the β-sitosterol emulsion. Increasing homogenization pressure and cycle led to improving emulsion stability and encapsulation efficiency. The β-sitosterol emulsion homogenised at 100 bar for 1 cycle had the highest encapsulation efficiency (81.7%) among all samples. The optimization study showed that the emulsification at 300 bar for 3 cycles resulted in the most desirable β-sitosterol emulsion.

Item Type:	Article (Journal)
Additional Information:	6605/60521
Uncontrolled Keywords:	β-Sitosterol, Phytosterol, Nanoemulsifiation, Encapsulation efficiency, Release behaviour, Emulsion stability, Cholesterol
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Professor Md. Zaidul Islam Sarker
Date Deposited:	28 Dec 2017 15:32
Last Modified:	19 Apr 2018 16:45
URI:	http://irep.iium.edu.my/id/eprint/60521

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