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Male infertility: The effect of natural antioxidants and phytocompounds on seminal oxidative stress

Adewoyin, Malik and Ibrahim, Muhammad and Roszaman, Ramli and Md Isa, Muhammad Lokman and Mat Alewi, Nur Aizura and Abdul Wafa, Ainin Azwani and Anuar, Mohd Nur Nasyriq (2017) Male infertility: The effect of natural antioxidants and phytocompounds on seminal oxidative stress. Diseases, 5 (1). pp. 1-26. ISSN 2079-9721

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Abstract

Defective sperm function has been identified as the most common cause of infertility. The objective of this study was to review recent findings on the effects of various antioxidants on male fertility. High amounts of poly unsaturated fatty acid are found in the mammalian spermatozoa membranes, thereby making them susceptible to lipid peroxidation. Although, free radicals and reactive oxygen species (ROS) play major roles in reproduction, they are strongly associated with oxidativestress. Furthermore,factorssuchasobesity,inflammation,pollutantsandcigarettesmoking are negatively correlated with spermatogenesis. Endogenous antioxidants system exists to mediate these damages. In a normal physiological state, the seminal plasma contains antioxidant enzyme mechanism that is capable of quenching these ROS as well as protecting the spermatozoa against any likely damage. However, high level of ROS triggered by inflammatory cells and oxidation of fatty acidinobesesubjectsmaydownplayantioxidantmechanismresultinginoxidativestress. Evaluation of such oxidative stress is the first step in the treatment of male infertility through administration of suitable antioxidant. Notably, antioxidant such as vitamin E and C, carotenoids and carnitine have been found beneficial in restoring a balance between ROS generation and scavenging activities. There are emerging evidences that herbal products can also boost male reproductive functions. Nonetheless, a good lifestyle, regular exercise, avoidance of stress and observing safety rules at work are habits that can reverse male infertility.

Item Type: Article (Journal)
Additional Information: 4998/57822
Uncontrolled Keywords: spermatozoa; reactive oxygen species; oxidative stress; antioxidants
Subjects: R Medicine > RM Therapeutics. Pharmacology > RM214 Diet therapy. Diet and dietectics in disease
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Allied Health Sciences > Department of Nutrition Sciences
Kulliyyah of Nursing
Depositing User: Muhammad Ibrahim
Date Deposited: 01 Aug 2017 10:47
Last Modified: 09 Feb 2018 19:08
URI: http://irep.iium.edu.my/id/eprint/57822

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