Baccaurea angulata fruit juice reduces atherosclerotic lesions in diet-induced Hypercholesterolemic rabbits

Ibrahim, Muhammad and Ahmed, Idris Adewale and Abimbola, Maryam Mikail and Ishola, Afeez Adekunle and Draman, Samsul and Md Isa, Muhammad Lokman and Mat Yusof, Afzan (2017) Baccaurea angulata fruit juice reduces atherosclerotic lesions in diet-induced Hypercholesterolemic rabbits. Lipids in Health and Disease, 16. pp. 1-8. ISSN 1476-511X

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Abstract

Background: Atherosclerosis is the most common disease of large and medium-sized arteries linked to oxidative stress, dyslipidemia as well as chronic inflammation. The aim of this study was to evaluate the potential health benefits of Baccaurea angulata (BA) fruit juice on the aorta of diet-induced hypercholesterolemic rabbits, to detect an accumulation of fatty streak and evaluate the percentage of atherosclerotic lesion accrued. Methods: Thirty-five healthy male adults New Zealand White rabbits were assigned to seven different groups. Four groups were fed 1% cholesterol diet and 0, 0.5, 1.0, and 1.5 mL of BA fruit juice per kg of rabbit daily (atherogenic groups), while the other three groups were fed commercial rabbit pellet and 0, 0.5, and 1.0 mL of juice per kg of rabbit daily (normocholesterolemic groups) for 90 days. The thoracic and abdominal aorta between the heart origin and bifurcation into iliac arteries of all the rabbits were carefully removed and analyzed accordingly. Results: The supplementation of the high-cholesterol diet of hypercholesterolemic rabbits with only 0.5 mL BA/kg rabbit per day significantly (p < 0.001) improved aortic lipid profile, attenuated aortic fatty streak development and reduced intima thickening. Higher BA doses used (1.0 and 1.5 mL/kg rabbit per day) also significantly (p < 0.001) decreased further the development of aortic fatty streaks, reduced the thickening of the tunica intima layer and preserved endothelial healing following arterial injury. Conclusion: Therefore, BA fruit is a potential novel functional food with effective anti-inflammatory, antiatherogenic and hypocholesterolemic activities.

Item Type:	Article (Journal)
Additional Information:	4998/57816
Uncontrolled Keywords:	Atherosclerosis, Hypercholesterolemia, Intima thickness, Lesion, Lipid profile
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM214 Diet therapy. Diet and dietectics in disease
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Nutrition Sciences
Depositing User:	Muhammad Ibrahim
Date Deposited:	01 Aug 2017 09:26
Last Modified:	05 Apr 2018 11:00
URI:	http://irep.iium.edu.my/id/eprint/57816

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