Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model

Abdul Rahim, Roslina and Badaruddin, Muhammad Taufiq and Ahmed, Qamar Uddin and Muhammad, Siti Aeshah @ Naznin (2017) Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model. UNSPECIFIED. UNSPECIFIED. (Unpublished)

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Abstract

Introduction: Nigella sativa has been reported to have anti-inflammatory and anti-oxidative properties. We aimed to investigate the effects of Nigella sativa oil extract on the high fat diet (HFD) fed animal model. Methods: Thirty male Sprague-Dawley rats were used. Four groups (n=7) were fed with high fat diet (HFD) rat pellet orally for 10 weeks. The rats with HFD groups were subsequently randomly divided again into 4 groups. One group was continued with HFD while the other 3 groups were continued with the HFD in addition to Nigella sativa oil extract treatment at three different concentrations (0.5, 1 and 1.5 ml/kg/day) for another 4 weeks. Blood biochemical analysis and histological assessment of liver were subsequently performed. Results: Animals fed with HFD had increased aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, cholesterol/HDL ratio, triglyceride (TG) levels, but decreased globulin, albumin/globulin ratio and high density lipoprotein (HDL) levels. Meanwhile, HFD animals treated with Nigella sativa oil extract showed a significant increase in the globulin and HDL levels, but reduced ALP, albumin, cholesterol/HDL ratio and TG levels. Nigella sativa oil extract at the higher doses displayed much better effect. Histologically the liver in all groups exhibited micro vesicular steatosis. Conclusions: Nigella sativa oil extracts improve the dyslipidaemia in animal models with HFD.

Item Type:	Monograph (UNSPECIFIED)
Additional Information:	5456/57071
Uncontrolled Keywords:	Nigella sativa, high fat diet, dyslipidaemia
Subjects:	Q Science > QP Physiology R Medicine > RA Public aspects of medicine R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr ROSLINA ABDUL RAHIM
Date Deposited:	25 May 2017 14:39
Last Modified:	06 Apr 2022 11:33
URI:	http://irep.iium.edu.my/id/eprint/57071

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