Tau protein as a biomarker for asphyxia: a possible forensic tool?

Salama, Mohamed and Mohamed, Wael Mohamed Yousef (2016) Tau protein as a biomarker for asphyxia: a possible forensic tool? Applied and Translational Genomics, 9. pp. 20-22. ISSN 2212-0661

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Abstract

Asphyxial death has been a problem for forensic investigations due to the absence of a validated biomarker for the diagnosis of this event. Recently, research on brain affection by asphyxia raised hopes on the possible use of CNSmarkers for asphyxia. The cytoskeletal proteins seemto be attractive targets as they are vulnerable to hypoxia and can be affected in asphyxial deaths. Tau, an important cytoskeletal protein, showed affection in many neurodegenerative disorders and recently in some acute incidences like trauma and brain ischemia. In this report we showthe affection of the normal pattern of tau and pathological aggregates of tau in the case of brain hypoxia. This may give new clues to asphyxial death investigations.

Item Type:	Article (Journal)
Additional Information:	7497/57059
Uncontrolled Keywords:	Asphyxia, Cytoskeletal proteins, Tau
Subjects:	R Medicine > RA Public aspects of medicine > RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine R Medicine > RA Public aspects of medicine > RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr Wael Mohamed
Date Deposited:	24 May 2017 15:54
Last Modified:	09 Oct 2017 16:17
URI:	http://irep.iium.edu.my/id/eprint/57059

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