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Assessment of Cox2 and CMV in patients with chronic HCV infection

F. Hassan, Heba and M. Khashman, Basim and A. Abdul Qader, Omer and W. Izzat, Alaa (2017) Assessment of Cox2 and CMV in patients with chronic HCV infection. Journal of Contemporary Medical Sciences (JOCMS), 3 (9 (Winter)). pp. 182-185. ISSN 2413-0516

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Abstract

Objective This study was established to determine the expression of COX-2 and CMV in patients with chronic C infection. Methods A total of 30 formalin-fixed of paraffin-embedded liver samples obtained from patients with chronic hepatitis C infection. In addition, 30 apparently normal liver autopsies were used as control group used for immunohistochemistry technique (IHC) to study the expression of cyclooxygenase (COX-2) and cytomegalovirus (CMV) in these samples. Results In current study, the results of expression of COX-2 were found in 25 cases (83.3%) of chronic HCV were strongly positive with a significant increase at P < 0.001, while the result of CMV expression was detected as brown cytoplasmic membranous staining of cells with positive CMV expression demonstrated in 21 (70.0%) out of 30 cases of chronic HCV infection cases. All control groups were negative for the expression of COX-2 and CMV. Conclusion This study concludes that COX-2 and CMV participates in the pathogenesis of chronic HCV infection. Keywords chronic HCV infection, cyclooxygenase (COX-2), cytomegalovirus (CMV)

Item Type: Article (Journal)
Additional Information: 7092/56689
Uncontrolled Keywords: chronic HCV infection, cyclooxygenase (COX-2), cytomegalovirus (CMV)
Subjects: R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Dentistry
Depositing User: Dr Omar Abdul jabbar
Date Deposited: 09 May 2017 11:29
Last Modified: 03 Apr 2018 16:21
URI: http://irep.iium.edu.my/id/eprint/56689

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