The cholesterol lowering effects of Eurycoma longifolia Jack (Tongkat Ali) root extract in male rats

Faisal, Ghasak Ghazi and Abllah, Zurainie and Najmuldeen, Ghazi Faisal and Al-Ani, Ali Sabri Radeef (2017) The cholesterol lowering effects of Eurycoma longifolia Jack (Tongkat Ali) root extract in male rats. Makara Journal of Health Research, 21 (1). pp. 25-29. ISSN 2356-3664 E-ISSN 2356-3656

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Abstract

Background: To investigate the effect of Eurycoma longifolia Jack root extract on serum lipids in rats. Methods: Twenty-six mature male albino Wistar rats were used in this study. A group of 18 rats were fed a high fat and high cholesterol diet for 4 weeks, after which their lipid profile was compared to the control group, who were kept on a normal diet. The rats were then further divided into three groups, the Cf group that continued to feed on a high fat and cholesterol diet only, and group A and group B who continued on a high fat diet with the addition of 5 mg/kg and 10 mg/kg of Eurycoma longifolia Jack root extract respectively for 4 weeks. After the 4 week period, the rat’s lipid profiles were analysed again. Results: Group A and B showed significant total cholesterol reduction when compared to the Cf group, 140 ± 7.23, 139.63 ± 7.95, 192.14 ± 8.96 mg/dL respectively (p < 0.001). The total cholesterol/HDL ratio in group A was 5 however there was a sharp increase in group B to a high-risk level of 9.2 indicating a significant drop in HDL levels. The LDL level increased significantly in both group A and B compared to the Cf group. Conclusions: Eurycoma longifolia Jack root extract is effective in lowering total cholesterol, however the dose needs to be adjusted to prevent an excessive decrease in HDL levels.

Item Type:	Article (Journal)
Additional Information:	6388/56299
Uncontrolled Keywords:	albino wistar rats, cholesterol, Eurycoma longifolia Jack, HDL, LDL
Subjects:	R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Medicine > Department of Psychiatry
Depositing User:	Assoc.Prof Ghasak Ghazi Al-Atrakchi
Date Deposited:	06 Apr 2017 16:04
Last Modified:	09 Oct 2017 15:35
URI:	http://irep.iium.edu.my/id/eprint/56299

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