Nephrotoxicity in chronic low dose organophosphate exposure

Aung, Sanda and Abdullah, Nor Zamzila and A.Talib, Norlelawati and Mohd Noor, Noriah and Harun, Norra and Mat Zainone, Zamzuria and Abdul Razak, Tariq (2016) Nephrotoxicity in chronic low dose organophosphate exposure. The Malaysian Journal of Pathology, 38 (2). p. 193. ISSN 0126-8635

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Abstract

Objectives: People are exposed to chronic low dose organophosphates (OPs) pesticides through agriculture and pest control activities. Apparently, there were signifcant epidemiological reports suggesting pesticides role in chronic kidney disease. This observation is yet to be confrmed with appropriate experimental model of chronic OPs exposure on animals. Thus, the aim of this study is to observe for histomorphological characteristics related to nephropathy in the kidneys of rats upon exposure to chronic low dose OPs. Materials and Methods: 24 males Sprague-Dawley rats were randomly divided into 3 groups of 6 rats each with Group 1 as a Control group, whilst Group 2 and Group 3 received subcutaneous vehicle (3% dimethyl sulphoxide + 97% v/v soy oil) and 18.0 mg/kg BW chlorpyrifos respectively, every other day for 180 days. After treatment, the rats were sacrifced and the right kidney was subjected to routine H&E examination and specifc Masson-Trichrome and periodic-acid Schiff stain. Results: OPs exposed group (Group 3) exhibited signifcant histo-morphological abnormalities suggesting cell injury, apoptosis and degenerative changes in glomeruli and tubules. In contrast, the control groups 1 and 2 (vehicle) are spared. Conclusion: Chronic low dose OPs exposure induced nephrotoxicity. The exact mechanism of nephrotoxicity should be further investigated.

Item Type:	Article (Journal)
Additional Information:	6385/55903
Uncontrolled Keywords:	Nephrotoxicity, chronic low dose organophosphate
Subjects:	R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Pharmacy > Department of Basic Medical Sciences
Depositing User:	Dr SANDA AUNG
Date Deposited:	23 Feb 2017 15:43
Last Modified:	17 Oct 2017 10:51
URI:	http://irep.iium.edu.my/id/eprint/55903

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