IIUM Repository (IREP)

Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger

Omar, Muhammad Nor and Hasali, Nor Hazwani and Yarmo, Mohd Ambar (2016) Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger. Oriental Journal of Chemistry, 32 (5). pp. 2732-2734. ISSN 0970-020X

[img] PDF - Published Version
Restricted to Repository staff only

Download (170kB) | Request a copy
[img] PDF (WOS) - Supplemental Material
Restricted to Repository staff only

Download (183kB) | Request a copy
[img] PDF (SCOPUS) - Supplemental Material
Restricted to Repository staff only

Download (146kB) | Request a copy

Abstract

The extraction of Kaempferia galanga rhizome using steam distillation and supercritical fluid extraction (SFE) was carried out. After fractionation, the major compound of the K. galanga extract, ethyl p-methoxycinnamate (EPMC) was transformed using Aspergillus niger into ethyl p-hydroxycinnamate (EPHC). The biological anticancer activity of EPMC and its biotransformed product (EPHC) was established by cytotoxicity activity on the human breast cancer (MCF-7) cell line using MTT assay. Ethyl p-hydroxycinnamate (EPHC) was most cytotoxic against MCF-7 at 1000 μg/mL where percentage of cell viability was 9.87 %, while IC50 was 340 μg/mL. EPHC showed slightly higher cytotoxicity activity compared to EPMC. The results of this study show that the biotransformation process was able to produce a metabolite (EPHC) with higher cytotoxicity activity compared to its parent compound (EPMC).

Item Type: Article (Journal)
Additional Information: 5626/54229
Uncontrolled Keywords: Kaempferia galanga, ethyl p-methoxycinnamate, biotransformation, cytotoxic.
Subjects: Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Science > Department of Biotechnology
Depositing User: Prof Dr Muhammad Nor Omar
Date Deposited: 16 Jan 2017 10:26
Last Modified: 21 Nov 2017 17:17
URI: http://irep.iium.edu.my/id/eprint/54229

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year