Production of polylactic acid nanoparticles encapsulating astaxanthin

Ibrahim Ali, Noorbatcha and Ahmad Zawawi, Ahmad Fandi and Ali, Fathilah and Jaswir, Irwandi (2016) Production of polylactic acid nanoparticles encapsulating astaxanthin. In: 4th International Conference on Biotechnology Engineering 2016 (ICBioE 2016), 25th-27th July 2016, Kuala Lumpur. (Unpublished)

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Abstract

Astaxanthin is one of the carotenoid that has high antioxidant characteristics among other carotenoids. Hence it can play an active role in the prevention of cancer and cardiovascular diseases. However, its use as a high value pharmaceutical product is limited by its low water solubility and bioavailability. Nanoencapsulation of active materials in a biodegradable polymer matrix can be used to alleviate this problem. In addition to increasing the stability of the active compounds inside the matrix, nanoencapsulation can also be used to manipulate the controlled and sustained release of active materials into the target area. Poly-lactic acid (PLA) is a good drug carrier based on its biodegradability and biocompatibility. PLA have been reported as an encapsulated material and delivery vehicle for several active compounds. In this study, PLA along with poly-vinyl alcohol (PVA) was used to encapsulate astaxanthin using single emulsion method. The effect of PLA and PVA concentration on drug loading and drug entrapment was analyzed, and the optimum conditions for high drug loading were found to be 8.71 mg of PLA and 8.26 % of PVA solution. The in-vitro drug release of astaxanthin from the nanoparticles shows an initial burst profile followed by a slow release until 24 hours.

Item Type:	Conference or Workshop Item (Slide Presentation)
Additional Information:	3704/53920
Uncontrolled Keywords:	polylactic acid, nanoparticles, astaxanthin
Subjects:	T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User:	Prof. Dr. Ibrahim Ali Noorbatcha
Date Deposited:	11 Jan 2017 09:03
Last Modified:	11 Jan 2017 09:03
URI:	http://irep.iium.edu.my/id/eprint/53920

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