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Histological evaluation of hydroxyapatite granules with and without platelet-rich plasma versus an autologous bone graft : comparative study of biomaterials used for spinal fusion in a New Zealand white rabbit model

Zakaria@Mohamad, Zamzuri and Che Seman, Che Nor Zarida and Buyong, Zunariah and Sharifudin, Mohd Ariff and Zulkifly, Ahmad Hafiz and Khalid, Kamarul Ariffin (2016) Histological evaluation of hydroxyapatite granules with and without platelet-rich plasma versus an autologous bone graft : comparative study of biomaterials used for spinal fusion in a New Zealand white rabbit model. Sultan Qaboos University Medical Journal, 16 (4). pp. 422-429. ISSN 2075-051X

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Abstract

Objectives: Hydroxyapatite (HA) has osteoconductive properties and is widely used as a bone graft substitute. Platelet-rich plasma (PRP) is an autologous product with osteoinductive effects. Hypothetically, a combination of both would augment the bone formation effect of HA and widen its application in spinal fusion surgeries. This study aimed to compare new bone formation with HA granules alone and in combination with PRP versus an autologous bone graft during a lumbar intertransverse process spinal fusion. Methods: A total of 16 adult New Zealand white rabbits underwent single-level bilateral intertransverse process fusion at the L5–L6 vertebrae. One side of the spine received either HA granules alone or a combination of HA granules and PRP, while the contralateral side received an autologous bone graft. Four animals each from the HA group and the HA plus PRP group versus the autograft group were assessed either at six or 16 weeks by undecalcified histology and histomorphometry. The mean percentage of new bone areas over the corresponding fusion masses were compared between groups. Results: No signi cant di erence in new bone formation was observed between the HA and HA plus PRP groups at six or 16 weeks. The autograft group had significantly more new bone formation at six and 16 weeks (P = 0.004 and <0.001, respectively). Conclusion: An autologous bone graft remains superior to HA granules, with or without PRP. HA granules demonstrated an excellent osteoconductive scaffold but had poor biodegradability. While PRP enhances the properties of HA granules, these biomaterials do not have a synergistic effect.

Item Type: Article (Journal)
Additional Information: 3660/53609
Uncontrolled Keywords: Autografting; Hydroxyapatite; Lumbar Vertebrae; Platelet-Rich Plasma; Spinal Fusion
Subjects: R Medicine > RB Pathology
R Medicine > RD Surgery > RD701 Orthopedics
R Medicine > RD Surgery > RD92 Wounds and injuries
R Medicine > RZ Other systems of medicine > RZ301 Osteopathy
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine > Department of Basic Medical
Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation
Depositing User: Dr MOHD ARIFF SHARIFUDIN
Date Deposited: 21 Dec 2016 11:11
Last Modified: 21 Mar 2017 18:11
URI: http://irep.iium.edu.my/id/eprint/53609

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