IIUM Repository (IREP)

Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model

Abdul Rahim, Roslina and Badaruddin, Muhammad Taufiq and Ahmed, Qamar Uddin and Muhammad, Siti Aesah @ Naznin (2016) Nigella sativa oil extracts improves dyslipidaemia in high fat diet (HFD) animal model. In: Medical Research Symposium & Pacific Partnership in conjunction with Kuantan Research Day 2016, 3rd-5th August 2016, Kuantan, Pahang, Malaysia. (Unpublished)

[img] PDF - Published Version
Restricted to Repository staff only

Download (15MB) | Request a copy


Introduction: Nigella sativa has been reported to have anti-inflammatory and anti-oxidative properties. We aimed to investigate the effects of Nigella sativa oil extract on the high fat diet (HFD) fed animal model. Methods: Thirty male Sprague-Dawley rats were used. Four groups (n=7) were fed with high fat diet (HFD) rat pellet orally for 10 weeks. The rats with HFD groups were subsequently randomly divided again into 4 groups. One group was continued with HFD while the other 3 groups were continued with the HFD in addition to Nigella sativa oil extract treatment at three different concentrations (0.5, 1 and 1.5 ml/kg/day) for another 4 weeks. Blood biochemical analysis and histological assessment of liver were subsequently performed. Results: Animals fed with HFD had increased aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, cholesterol/HDL ratio, triglyceride (TG) levels, but decreased globulin, albumin/globulin ratio and high density lipoprotein (HDL) levels. Meanwhile, HFD animals treated with Nigella sativa oil extract showed a significant increase in the globulin and HDL levels, but reduced ALP, albumin, cholesterol/HDL ratio and TG levels. Nigella sativa oil extract at the higher doses displayed much better effect. Histologically the liver in all groups exhibited micro vesicular steatosis. Conclusions: Nigella sativa oil extracts improve the dyslipidaemia in animal models with HFD.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 5456/51856
Uncontrolled Keywords: Nigella sativa, high fat diet, dyslipidaemia
Subjects: Q Science > QP Physiology
R Medicine > RB Pathology
R Medicine > RC Internal medicine
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine > Department of Basic Medical
Kulliyyah of Pharmacy
Date Deposited: 09 Sep 2016 09:55
Last Modified: 09 Sep 2016 09:55
URI: http://irep.iium.edu.my/id/eprint/51856

Actions (login required)

View Item View Item


Downloads per month over past year