A review on anticancer and biochemical properties of Clinacanthus nutans

Zakaria, Khairun Najwa and Amid, Azura (2016) A review on anticancer and biochemical properties of Clinacanthus nutans. In: 4th International Conference on Biotechnology Engineering 2016 (ICBioE 2016), 25th-27th July 2016, Kuala Lumpur.

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Abstract

Clinacanthus nutans (CN) (Belalai Gajah in Malay) is often used as herbal remedies complementary. The extracts from its dried leaves has been used traditionally to treat disease such as anti-venom for snake/insect bite. Phytochemical screening showed that the extract comprises of lupeol,  –sitosterol, stigmasterol, Botulin, myricyl alcohol C-glycosyl flavones (vitexin, isovitexin, shaftoside, isomollupentin 7-O-b -glucopyranoside, orientin and isoorientin), sulfur-containing glucosides, cerebrosides mixer, a monoacylmonogalactosylglycerol, 13-hydroxy-(13-S)-phaeophytin b, Pupurin-18-phytyl ester, phaeophorbide and chlorophyll derivatives. Literature search showed that the ethanolic extract of CN had an antioxidant activity and protective effect against free radical. Experimental evidences confirmed that the CN could be used in treating tumor and cancer since it showed anticancer and antiproliferative properties. Its petroleum ether extracts also demonstrated the strongest cytotoxic activity against HeLa and K-562 cells. The bioactive compounds from CN are potential cytotoxic, antioxidant and antiproliferative properties against cultured cancer cell lines, suggesting an alternate adjunctive regimen for cancer prevention or treatment.

Item Type:	Conference or Workshop Item (Invited Papers)
Additional Information:	3688/51801
Uncontrolled Keywords:	acanthaeae, clinacanthus nutans, anticancer,antioxidant
Subjects:	R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User:	Prof Ts Dr Azura Amid
Date Deposited:	25 Aug 2016 14:41
Last Modified:	13 Jan 2017 10:40
URI:	http://irep.iium.edu.my/id/eprint/51801

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