Relationship of Cyclin D1 expression, Estrogen Receptor status and Histological grading in Invasive Duct Carcinoma of the breast

Sanda, Aung and Aye Aye , Thike and Tha, Aung (2011) Relationship of Cyclin D1 expression, Estrogen Receptor status and Histological grading in Invasive Duct Carcinoma of the breast. Myanmar Journal of Current Medical Practice, 15 (2). pp. 2-8.

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Abstract

Invasive duct carcinoma of the breast is a clinically and biologically heterogeneous disease. Histological grading was done according to Modified Bloom and Richardson Grading in 40 cases of formalin fixed, paraffin embedded tissue sections of Invasive duct carcinoma (NST). Estrogen receptor (ER) status and Cyclin D1 expression were detected by standard immunohistochemistry. Cyclin D1 expression was detected in 43% (17 of 40) of cases, and was inversely associated (x2 test) with histological grade (p=0.01). ER immunoreactivity was found in 30% (12 of 40) of patients and was inversely associated with histological grade (p=0.021). Cyclin D1 immunoreactivity was positively associated with estrogen receptor expression (p=0.043). There was no significant correlation with clinical prognostic parameters of age, menopausal status, tumour size and clinical stage.

Item Type:	Article (Journal)
Additional Information:	6385/5087
Uncontrolled Keywords:	Cyclin D1, Invasive duct carcinoma,
Subjects:	R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy
Depositing User:	Dr SANDA AUNG
Date Deposited:	08 Dec 2011 15:55
Last Modified:	05 Sep 2013 13:26
URI:	http://irep.iium.edu.my/id/eprint/5087

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