IIUM Repository (IREP)

Blood-pressure lowering in intermediate-risk persons without cardiovascular disease

Lonn, Eva M. and Bosch, Jackie and López‑Jaramillo, Patricio and Jun, Zhu and Lisheng, Liu and Pais, Prem and Md Aris, Mohd Aznan and Mohd Shah, Azarisman Shah and ., et. al (2016) Blood-pressure lowering in intermediate-risk persons without cardiovascular disease. New England Journal of Medicine, 374 (21). pp. 2009-2020. ISSN 0028-4793

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Official URL: htpp://www.nejm.org.com

Abstract

Antihypertensive therapy reduces the risk of cardiovascular events among high-risk persons and among those with a systolic blood pressure of 160 mm Hg or higher,but its role in persons at intermediate risk and with lower blood pressure is unclear In one comparison from a 2-by-2 factorial trial, we randomly assigned 12,705 participants at intermediate risk who did not have cardiovascular disease to receive either candesartan at a dose of 16 mg per day plus hydrochlorothiazide at a dose of 12.5 mg per day or placebo. The first coprimary outcome was the composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke; the second coprimary outcome additionally included resuscitated cardiac arrest, heart failure, and revascularization. The median follow-up was 5.6 years.

Item Type: Article (Journal)
Additional Information: 4632/50354 This project has more than 440 collaborators.The list of complete collaborators is available in the supplementary document. For repository purpose we have to shortened to IIUM names.
Uncontrolled Keywords: blood-pressure
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
R Medicine > RJ Pediatrics
R Medicine > RZ Other systems of medicine
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine > Department of Family Medicine (Effective: 1st January 2011)
Kulliyyah of Medicine > Department of Internal Medicine
Depositing User: SR NUR FARHANA LATFI
Date Deposited: 30 May 2016 09:05
Last Modified: 22 May 2018 11:24
URI: http://irep.iium.edu.my/id/eprint/50354

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