Effect of cinnamon extract on blood glucose level and pancreas histopathology in diabetic rats

Nor Adilah , Abdul Ghani and Azzubaidi, Marwan Saad and Al-Ani, Imad Matloub Dally (2016) Effect of cinnamon extract on blood glucose level and pancreas histopathology in diabetic rats. Annals of Microscopy, 15 (1). pp. 57-64. ISSN 0219-2209

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Abstract

The purpose of this research is to evaluate the effect of standardized cinnamon extract (CE) on fasting blood glucose (FBG) level and histopathological changes in islets of Langerhans in streptozotocin-induced diabetic rats (STZ). Twenty fi ve rats were divided into fi ve groups (n=6); normal control, normal treated with “CE” control, diabetic control (non-treated with “CE”), diabetic treated with 200mg/kg CE aqueous extract and diabetic treated with 0.5mg/kg glibenclamide (GLB). All the drugs were given orally as a single daily dose for 30 days. The FBG was determined once per week using Glucometer from rat tail vein. On the fi rst and second week, the 2 groups of diabetic rats treated with CE and GLB showed no significant differences of FBG as compared to control group. On the subsequent weeks only GLB-treated group showed no significant differences in FBG compared to the normal control. Histology observation revealed that both CE and GLB treated group showing restoration of the normal architecture of the islet structure compared with STZ untreated group which appeared as shrunken islet with degranulated β-cells, and pyknotic nuclei. It is concluded that both CE and GLB treated groups demonstrated significantly lower FBG than that of STZ group. CE proved to be effective in reducing FBG in diabetic rats, but it was less potent than GLB.

Item Type:	Article (Journal)
Additional Information:	6809/50298
Uncontrolled Keywords:	Diabetes Mellitus, Streptozotocin, cinnamon, Glibenclamide, Islets of Langerhans
Subjects:	Q Science > QP Physiology R Medicine > R Medicine (General) R Medicine > RB Pathology R Medicine > RM Therapeutics. Pharmacology R Medicine > RM Therapeutics. Pharmacology > RM283 Endocrinotheraphy
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Pharmacy > Department of Basic Medical Sciences
Depositing User:	Dr. Marwan Saad Azzubaidi
Date Deposited:	04 May 2016 14:48
Last Modified:	15 Jul 2016 16:09
URI:	http://irep.iium.edu.my/id/eprint/50298

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