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Extraction and isolation of xanthine oxidase inhibitors from carica papaya leave extract using chromatographic techniques

Jamal, Parveen and Azmi, Saiful Mohammad Nizam and Amid, Azura (2016) Extraction and isolation of xanthine oxidase inhibitors from carica papaya leave extract using chromatographic techniques. In: Experimental methods in modern biotechnology. IIUM Press Series of Textbook from the Islamic Perspectives, 2 . IIUM Press, Kuala Lumpur, pp. 25-35. ISBN 978-967-418-384-4

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Abstract

Xanthine oxidase (XO) is a key enzyme that catalyses the oxidation of oxypurines (hypoxanthine and xanthine) to uric acid in the purine metabolic pathway.The increase level of uric acid in the blood serum is called hyperuricemia. Its major complications are gout, urolithiasis and reactive oxygen production. In addition, some diseases are frequently seen with elevated uric acid concentration such as cardiovascular disease and renal insufficiency (Nakagawa et al., 2006), although no direct role has yet been confirmed. Xanthine oxidase inhibitor (XOI) could block the biosynthesis of uric acid from purine in the body, which should be one of the therapeutic approaches for treating hyperuricemia.

Item Type: Book Chapter
Additional Information: 2937/49678
Uncontrolled Keywords: xanthine oxidase inhibitors, carica papaya leave
Subjects: T Technology > T Technology (General)
T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Engineering
Depositing User: Prof.Dr. Parveen Jamal
Date Deposited: 19 Feb 2016 09:03
Last Modified: 21 Feb 2017 10:09
URI: http://irep.iium.edu.my/id/eprint/49678

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