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Simulation and experimental measurement of acoustic intensity on sonication parameters and decellularization using sonication treatment

., Nurul Syazwani and Shafiq, Mohammad and Ushida, Takashi and Noor Azmi, Azran Azhim (2015) Simulation and experimental measurement of acoustic intensity on sonication parameters and decellularization using sonication treatment. Journal of Signal Processing, 19 (4). pp. 179-182. ISSN 1880-1013

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Abstract

A novel sonication decellularization system is developed to prepare complete decellularized tissue. The objective of the study is to determine the influence of acoustic intensity on sonication parameter and decellularization using sonication treatment. The distribution of acoustic intensity for sonication treatment is first demonstrated by simulation followed by experimental measurement. The relation of acoustic intensity with sonication parameter on decellularization is further investigated. The effect of acoustic intensity on decellularization is evaluated by measuring the residual cell in tissue sample using Hematoxylin-Eosin staining. The simulation shows low residual cells upon high acoustic intensity. From the result, acoustic intensity shows positive correlation with dissolved oxygen concentration and pH and negative correlation with conductivity. The present study concludes that decellularization performed by sonication treatment is dependent on acoustic intensity.

Item Type: Article (Journal)
Additional Information: 7380/44506
Uncontrolled Keywords: acoustic intensity, sonication parameters
Subjects: T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Science > Department of Biotechnology
Depositing User: Ir Dr Azran Azhim Noor Azmi
Date Deposited: 03 Sep 2015 11:20
Last Modified: 16 Jun 2017 09:22
URI: http://irep.iium.edu.my/id/eprint/44506

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