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Antiproliferative activity of selected prophetic medicinal plants on human lung adenocarcinoma cells, A549

Abdul Ghani, Radiah and Jamil, Elyna Fatini and Nor Azahan Shah, Nor Azni Masturah and Nik Abdul Malek, Nik Nurasyikin (2015) Antiproliferative activity of selected prophetic medicinal plants on human lung adenocarcinoma cells, A549. In: International Conference on Advancement in Science and Technology (iCAST 2015) - ‘Frontiers in Biotechnology’, 10-12 August 2015, Impiana Resort Cherating, Pahang, Malaysia. (Unpublished)

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Abstract

Introduction: Cancer incidence has shown marked increase over the years that lead to significant interest in disease prevention strategies. Chemoprevention is one of the potential approaches using natural, synthetic or biological agents that are able to delay, reverse, or prevent cancer initiation. Using natural agents of recommended prophetic medicinal plants is our main focus owing to not much study has elaborated on them. Therefore, the aim of the present study is to investigate the effect of selected prophetic medicinal plants as potential cancer chemopreventive agents using fig (Ficus auriculata), dates (Phoenix dactylifera), and raisin (Vitis vinifera) against A549 cells. Methods: The plants were freeze dried with freeze-drying machine, diluted to a certain concentration and tested for antiproliferative activity using MTT and trypan blue (TB) exclusion assay. IC50, cell number and cell viability (%) were determined. Results: All plants showed significant dose-response relationship against A549. Fig and dates inhibited 50% of the cell population at concentration of 25 mg/ml while raisin at 30 mg/ml respectively. Growth curve indicated cell number was reduced over time from 0 to 144 hour and cell viability was ranged from 98.4-0%. Conclusion: The results suggested that selected prophetic medicinal plants tested displayed growth inhibitory effect in A549 cells.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 4458/44456
Uncontrolled Keywords: cancer, antiproliferative, chemopreventive
Subjects: R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User: Dr Radiah Abdul Ghani
Date Deposited: 28 Aug 2015 15:50
Last Modified: 28 Aug 2015 15:50
URI: http://irep.iium.edu.my/id/eprint/44456

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