Carica papaya induces in vitro thrombopoietic cytokines secretion by mesenchymal stem cells and haematopoietic cells

Aziz, Jazli and Abu Kassim , Noor Lide and Abu Kasim, Noor Hayaty and Haque, Nazmul and Rahman, Mohammad Tariqur (2015) Carica papaya induces in vitro thrombopoietic cytokines secretion by mesenchymal stem cells and haematopoietic cells. BMC Complementary and Alternative Medicine, 15 (215). pp. 1-8. ISSN 1472-6882

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Abstract

Background Use of Carica papaya leaf extracts, reported to improve thrombocyte counts in dengue patients, demands further analysis on the underlying mechanism of its thrombopoietic cytokines induction Methods In vitro cultures of peripheral blood leukocytes (PBL) and stem cells from human exfoliated deciduous teeth (SHED) were treated with unripe papaya pulp juice (UPJ) to evaluate its potential to induce thrombopoietic cytokines (IL-6 and SCF) Results In vitro scratch gap closure was significantly faster (p < .05) in SHED culture treated with UPJ. IL-6 concentration was significantly increased (p < .05) in SHED and PBL culture supernatant when treated with UPJ. SCF synthesis in SHED culture was also significantly increased (p < .05) when treated with UPJ Conclusion In vitro upregulated synthesis of IL −6 and SCF both in PBL and SHED reveals the potential mechanism of unripe papaya to induce thrombopoietic cytokines synthesis in cells of hematopoietic and mesenchymal origin.

Item Type:	Article (Journal)
Additional Information:	778/43959
Uncontrolled Keywords:	Dengue fever; Megakaryopoiesis; Thrombocytes; Interleukin-6; Stem cell Factor
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science
Depositing User:	Prof Dr Noor Lide Abu Kassim
Date Deposited:	27 Jul 2015 11:03
Last Modified:	05 Mar 2019 12:22
URI:	http://irep.iium.edu.my/id/eprint/43959

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